(4-fluorophenyl)-[1-[3-[(4Z)-4-hydroxyimino-5-methyl-1,1-dioxo-3H-pyrrolo[2,3-e]thiazin-2-yl]propyl]piperidin-4-yl]methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-fluorophenyl)-[1-[3-[(4Z)-4-hydroxyimino-5-methyl-1,1-dioxo-3H-pyrrolo[2,3-e]thiazin-2-yl]propyl]piperidin-4-yl]methanone
• 化学式: C₂₂H₂₇FN₄O₄S
• 分子量: 462.5
• InChiKey: ABVYFXPRQFNPLE-CLCOLTQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action
  申请人：SUNTORY LIMITED

  公开号：US20020040017A1

  公开（公告）日：2002-04-04

  A pyrrolesulfonamide derivative having the following formula (I): 1 wherein the ring P represented by 2 is a pyrrole ring having the following structure: 3 wherein R represents alkyl, cycloalkyl, cycloalkylalkyl or aralkyl; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z 2 is not present and Z 1 represents H but, when the bond is absent, Z 1 represents H and Z 2 represents OH or Z 1 and Z 2 are combined together to represent O or a group NOR 1 , in which R 1 represents H, or alkyl, aralkyl or aryl; l stands for 0 or 1; A represents alkylene, alkenylene or alkynylene; and Y represents a group 4 in which W represents CH, C═ or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C═; B represents a specific divalent group; E 1 and E 2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances.

  具有以下式子（I）的吡咯磺酰胺衍生物：其中由2表示的环P是具有以下结构的吡咯环：其中R代表烷基，环烷基，环烷基烷基或芳基烷基；虚线表示键的存在或不存在；当键存在时，Z2不存在且Z1代表H，但当键不存在时，Z1代表H且Z2代表OH或Z1和Z2组合在一起表示O或NOR1基团，其中R1代表H，或烷基，芳基烷基或芳基；l代表0或1；A代表烷基，烯基或炔基；Y代表一个含有4的基团，其中W代表CH，C═或N；当W为CH或N时，m代表0或1，当W为C═时，m代表1；B表示特定的二价基团；E1和E2分别表示H或低烷基；D表示芳香族烃基或杂环基团。化合物（I）具有强烈的5-羟色胺2受体拮抗作用，毒性低，副作用少，可用于治疗缺血性心脏病，脑血管障碍和外周循环障碍等循环系统疾病。
• PYRROLOTHIAZINE AND PYRROLOTHIAZEPHINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION
  申请人：MIZUNO Akira

  公开号：US20050038242A2

  公开（公告）日：2005-02-17

  Abstract of the Disclosure A pyrrolesulfonamide derivative, Compound (I), which has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances.

  本发明涉及一种吡咯磺酰胺衍生物，化合物（I），其具有强烈的5-羟色胺2受体拮抗作用，毒性低且副作用较少，可用于治疗循环系统疾病，如缺血性心脏病、脑血管障碍和周围循环障碍。
• US6271223B1
  申请人：——

  公开号：US6271223B1

  公开（公告）日：2001-08-07
• US6624314B2
  申请人：——

  公开号：US6624314B2

  公开（公告）日：2003-09-23
• US7057036B2
  申请人：——

  公开号：US7057036B2

  公开（公告）日：2006-06-06