N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(2-chlorobenzoyl)-N-methyl-6-(4-methylpiperazin-1-yl)pyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(2-chlorobenzoyl)-N-methyl-6-(4-methylpiperazin-1-yl)pyridine-3-carboxamide
• 化学式: C₂₈H₂₅ClF₆N₄O₂
• 分子量: 599.0
• InChiKey: RCDCKKVXQMPIPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  56.8
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• Phenyl substituted pyridine and benzene derivatives
  申请人：——

  公开号：US20020111367A1

  公开（公告）日：2002-08-15

  The present invention is a series of compounds formed from phenyl substituted pyridine or benzene derivatives and their pharmaceutically acceptable salts. These compounds have shown high affinity as antagonists to the NK- 1 receptor.

  本发明是一系列由苯基取代的吡啶或苯衍生物及其药学上可接受的盐所形成的化合物。这些化合物已经表现出高亲和力作为NK-1受体的拮抗剂。
• Brain, spinal, and nerve injury treatment
  申请人：EUSTRALIS PHARMACEUTICALS LIMITED

  公开号：US10201568B2

  公开（公告）日：2019-02-12

  A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium compound.

  一种治疗脑、脊柱和神经损伤的方法，包括使用一种 P 物质受体拮抗剂（可选择与一种镁化合物结合使用）。还提供了一种用于这种治疗的制剂，包括一种 P 物质受体拮抗剂和一种镁化合物。
• Brain, spinal and nerve injury treatment
  申请人：Nimmo John Alan

  公开号：US20050107380A1

  公开（公告）日：2005-05-19

  A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium compound.

  一种治疗脑、脊柱和神经损伤的方法，包括使用一种 P 物质受体拮抗剂（可选择与一种镁化合物结合使用）。还提供了一种用于这种治疗的制剂，包括一种 P 物质受体拮抗剂和一种镁化合物。
• PHENYL- AND PYRIDINYL DERIVATIVES AS NEUROKININ 1 ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1157006A2

  公开（公告）日：2001-11-28
• Brain, Spinal and Nerve Injury Treatment
  申请人：Nimmo Alan John

  公开号：US20090253698A1

  公开（公告）日：2009-10-08

  A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium compound.