(E)-6-methylhept-4-en-2-yn-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-6-methylhept-4-en-2-yn-1-ol
• 化学式: C₈H₁₂O
• 分子量: 124.183
• InChiKey: RTELCBMNXVCLKE-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异丙基氯化镁 、 (E)-5-chloro-pent-4-en-2-yn-1-ol 在 iron(III)-acetylacetonate N-甲基吡咯烷酮 作用下， 以 四氢呋喃 为溶剂， 以52%的产率得到(E)-6-methylhept-4-en-2-yn-1-ol
  参考文献：
  名称：

  Regiocontrol of the Palladium-Catalyzed Tin Hydride Addition to Z-Enynols:  Remarkable Z-Directing Effects

  摘要：

  [GRAPHICS]Palladium-catalyzed hydrostannation of substituted Z- and E-enynols is discussed and compared. The regioselectivity of the H-Sn bond addition was found to be controlled by the geometry of the double bond ( Z- or syn-directing effect) rather than the nature of its substituents. Exclusively alpha-vinyl stannanes were obtained from Z-enynols having various substituents on the double bond regardless of their electronic, steric, or chelating natures.

  DOI：

  10.1021/jo0701435

文献信息

• Regiocontrol of the Palladium-Catalyzed Tin Hydride Addition to <i>Z</i>-Enynols:  Remarkable <i>Z</i>-Directing Effects
  作者：Abdallah Hamze、Olivier Provot、Jean-Daniel Brion、Mouâd Alami

  DOI：10.1021/jo0701435

  日期：2007.5.1

  [GRAPHICS]Palladium-catalyzed hydrostannation of substituted Z- and E-enynols is discussed and compared. The regioselectivity of the H-Sn bond addition was found to be controlled by the geometry of the double bond ( Z- or syn-directing effect) rather than the nature of its substituents. Exclusively alpha-vinyl stannanes were obtained from Z-enynols having various substituents on the double bond regardless of their electronic, steric, or chelating natures.