[1-(2-Amino-3-phenylpropyl)piperidin-4-yl]-(4-fluorophenyl)methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [1-(2-Amino-3-phenylpropyl)piperidin-4-yl]-(4-fluorophenyl)methanone
• 化学式: C₂₁H₂₅FN₂O
• 分子量: 340.4
• InChiKey: HYDREGQZRZGZDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PIPERIDINE COMPOUNDS FOR USE AS CCR-3 INHIBITORS
  申请人：Novartis AG

  公开号：EP1303488A1

  公开（公告）日：2003-04-23
• US6670379B2
  申请人：——

  公开号：US6670379B2

  公开（公告）日：2003-12-30
• US7078537B2
  申请人：——

  公开号：US7078537B2

  公开（公告）日：2006-07-18
• [EN] PIPERIDINE COUMPOUNDS FOR USE AS CCR-3 INHIBITORS<br/>[FR] COMPOSES DE PIPERIDINE S'UTILISANT EN TANT QU'INHIBITEURS CCR-3
  申请人：NOVARTIS AG

  公开号：WO2002004420A1

  公开（公告）日：2002-01-17

  Compounds of formula (I) in free or salt form, where Ar1 is phenyl substituted by one or more halogen atoms, Ar¿2? is phenyl or naphthyl which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy or C1-C8-alkoxycarbonyl, R?1¿ is hydrogen or C¿1?-C8-alkyl optionally substituted by hydroxy, C1-C8-alkoxy, acyloxy, N(R?2)R3¿, halogen, carboxy, C¿1?-C8-alkoxycarbonyl, -CON(R?4)R5¿ or by a monovalent cyclic organic group, R?2 and R3¿ are each independently hydrogen or C¿1?-C8-alkyl, or R?2¿ is hydrogen and R3 is acyl or -SO¿2?R?6, or R2 and R3¿ together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R?4 and R5¿ are each independently hydrogen or C¿1?-C8-alkyl, or R?4 and R5¿ together with the nitrogen atom to which they are attached denote a 5- 6-membered heterocyclic group, R6 is C1-C8-alkyl, C1-C8-haloalkyl, or phenyl optionally substituted by C1-C8-alkyl, and n is 1, 2, 3, or 4, with the proviso that when Ar1 is p-chlorophenyl and R1 is hydrogen, Ar2 is not phenyl or p-nitrophenyl. The compounds are useful as pharmaceuticals.