5-methyl-2-furyl 4-(2-tolylamino)-2-chlorophenyl ketone | 473423-12-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-methyl-2-furyl 4-(2-tolylamino)-2-chlorophenyl ketone
• 英文别名: 5-methyl-furan-2-yl 4-(2-tolylamino)-2-chlorophenyl ketone；[2-Chloro-4-(2-methylanilino)phenyl]-(5-methylfuran-2-yl)methanone
• CAS: 473423-12-0
• 化学式: C₁₉H₁₆ClNO₂
• 分子量: 325.795
• InChiKey: NNGNKKGFZBXQNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel aminophenyl ketone derivatives
  申请人：——

  公开号：US20030073832A1

  公开（公告）日：2003-04-17

  Novel heteroaryl aminophenyl ketone derivatives which are inhibitors of MAP kinases, in particular the p38 MAP kinase, are useful as anti-inflammatory agents in the prophylaxis or treatment of inflammatory diseases or conditions.

  新颖的杂环烷基氨基苯酮衍生物是MAP激酶的抑制剂，特别是p38 MAP激酶，在预防或治疗炎症性疾病或症状中作为抗炎药物是有用的。
• [EN] NOVEL AMINOPHENYL KETONE DERIVATIVES<br/>[FR] NOUVEAUX DERIVES D'AMINOPHENYLE CETONE
  申请人：LEO PHARMA AS

  公开号：WO2002083622A2

  公开（公告）日：2002-10-24

  Novel heteroaryl aminophenyl ketone derivatives which are inhibitors of MAP kinases, in particular the p38 MAP kinase, are useful as anti-inflammatory agents in the prophylaxis or treatment of inflammatory diseases or conditions.