1,4-Dideoxy-1,4-imino-(2-o-beta-d-glucopyranosyl)-d-arabinitol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-Dideoxy-1,4-imino-(2-o-beta-d-glucopyranosyl)-d-arabinitol
• 英文别名: (2R,3R,4S,5S,6R)-2-[(3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₁₁H₂₁NO₈
• 分子量: 295.29
• InChiKey: KCSBPSPWZAGWAF-SJXPRXMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  152
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• THE USE OF THE EFFECTIVE SECTION OF ALKALOIDS FROM RAMULUS MORI FOR PREPARATION OF A HYPOGLYCEMIG AGENT
  申请人：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP2255822A1

  公开（公告）日：2010-12-01

  The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.

  本发明涉及一种生物碱有效成分，该有效成分由桑树枝条制备而成，其有效成分为生物碱成分。经高效液相色谱法测定，有效成分中生物碱的总重量百分比为 50%或以上，化合物 1-脱氧野尻霉素的总重量百分比为 30%或以上。本发明有效馏分的制备步骤如下：桑枝经溶剂提取，提取液经醇沉或絮凝沉淀除去杂质，浓缩后经树脂色谱纯化，得到有效馏分。本发明还涉及一种含有所述生物碱有效成分的药物组合物，以及根据权利要求1-4所述生物碱有效成分在制备降血糖药中的应用。
• THE USE OF THE EFFECTIVE FRACTION OF ALKALOIDS FROM MULBERRY TWIG IN PREPARING HYPOGLYCEMIC AGENTS
  申请人：Liu Yuling

  公开号：US20110130352A1

  公开（公告）日：2011-06-02

  The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1 - 4 in preparing hypoglycemic agents.
• US9066960B2
  申请人：——

  公开号：US9066960B2

  公开（公告）日：2015-06-30