saccopetrin A

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: saccopetrin A
• 英文别名: (3R,5S)-5-(hydroxymethyl)-3-icos-19-en-11-ynyloxolan-2-one
• 化学式: C₂₅H₄₂O₃
• 分子量: 390.607
• InChiKey: PDSBIIGAXPWHRT-RPWUZVMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  saccopetrin A 、 碘甲烷 在 silver(l) oxide 作用下， 以89%的产率得到methylsaccopetrin A
  参考文献：
  名称：

  Saccopetrins A and B, Two Novel γ-Lactones from Saccopetalum prolificum

  摘要：

  Two new γ-lactones, saccopetrin A (1) and saccopetrin B (2), together with 10 known compounds have been isolated from the roots of Saccopetalum prolificum. Their structures were established by spectroscopic and chemical methods. The absolute configuration of 1 was determined by chemical transformation and the Mosher method. Cytotoxic activities were evaluated against several different cell lines. Compound 2 exhibited stronger cytotoxic activities than 1 against KB and HCT-8 cell lines at a concentration of 10-5 mol/L.

  DOI：

  10.1055/s-2002-33804

文献信息

• Saccopetrins A and B, Two Novel γ-Lactones from Saccopetalum prolificum
  作者：Ming-Lei Wang、Jiang Du、Pei-Cheng Zhang、Ruo-Yun Chen、Fei-Zhi Xie、Bin Zhao、De-Quan Yu

  DOI：10.1055/s-2002-33804

  日期：2002.8

  Two new γ-lactones, saccopetrin A (1) and saccopetrin B (2), together with 10 known compounds have been isolated from the roots of Saccopetalum prolificum. Their structures were established by spectroscopic and chemical methods. The absolute configuration of 1 was determined by chemical transformation and the Mosher method. Cytotoxic activities were evaluated against several different cell lines. Compound 2 exhibited stronger cytotoxic activities than 1 against KB and HCT-8 cell lines at a concentration of 10-5 mol/L.