4-(2,4-dimethylphenyl)-N-[[(5S)-3-(3-fluoro-4-pyrrolidin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-4-oxobutanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2,4-dimethylphenyl)-N-[[(5S)-3-(3-fluoro-4-pyrrolidin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-4-oxobutanamide
• 化学式: C₂₆H₃₀FN₃O₄
• 分子量: 467.5
• InChiKey: PMBTUXZLUAKHAS-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  79
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Novel antimycobacterial compounds
  申请人：Arora Kumar Sudershan

  公开号：US20050192275A1

  公开（公告）日：2005-09-01

  Novel compounds belonging to the class of oxazolidinones possessing potent antimycobacterial properties especially useful in the treatment of acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium -intracellular complex, M. fortuitum and M. kansai . The compound and its pharmaceutically acceptable salts thereof act as antibacterial agents. Also disclosed is a method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial conditions such as Mycobacterium tuberculosis , drug resistant Mycobacterium tuberculosis, Mycobacterium avium -intracellular complex, M. fortuitum and M. kansai , comprising administering an antimycobacterially effective amount of the said compound and/or pharmaceutically acceptable salts thereof. There is also disclosed a process for the manufacture of the said compound or its pharmaceutically acceptable salts.

  本发明涉及一类属于噁唑烷酮类的新化合物，具有强大的抗结核分枝杆菌的特性，尤其适用于治疗酸性快速生长的微生物，如结核分枝杆菌、肺巨细胞分枝杆菌、幸福分枝杆菌和关西分枝杆菌等。该化合物及其药用盐作为抗菌剂。本发明还公开了一种抑制分枝杆菌细胞生长的方法，以及一种治疗分枝杆菌感染的方法，如结核分枝杆菌、耐药结核分枝杆菌、肺巨细胞分枝杆菌、幸福分枝杆菌和关西分枝杆菌等，包括给予所述化合物和/或其药用盐的抗分枝杆菌有效量。本发明还公开了一种制备所述化合物或其药用盐的方法。
• US7691889B2
  申请人：——

  公开号：US7691889B2

  公开（公告）日：2010-04-06