N-methyl-4-[3-[[2-(trifluoromethyl)-3H-benzimidazol-5-yl]carbamoylamino]phenoxy]pyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-methyl-4-[3-[[2-(trifluoromethyl)-3H-benzimidazol-5-yl]carbamoylamino]phenoxy]pyridine-2-carboxamide
• 化学式: C₂₂H₁₇F₃N₆O₃
• 分子量: 470.4
• InChiKey: XEKKKMWDVVQTMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders
  申请人：Dumas Jacques

  公开号：US20050038031A1

  公开（公告）日：2005-02-17

  This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.

  本发明涉及新型二芳基脲、含有这些化合物的药物组合物以及使用这些化合物或组合物治疗过度增殖和血管生成障碍的方法，可以作为单一药物或与细胞毒性治疗联合使用。
• NOVEL BICYCLIC UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP1608639A2

  公开（公告）日：2005-12-28
• US8076488B2
  申请人：——

  公开号：US8076488B2

  公开（公告）日：2011-12-13
• [EN] NOVEL BICYCLIC UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS<br/>[FR] NOUVEAUX DERIVES BICYCLIQUES D'UREE UTILES DANS LE TRAITEMENT DU CANCER ET D'AUTRES TROUBLES
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2004078748A2

  公开（公告）日：2004-09-16

  This invention relates to novel diary) ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.