4-[4-[3-[4-chloro-3-(trifluoromethyl)phenyl]-5-(3-hydroxypropyl)-2-oxo-1,3,5-triazinan-1-yl]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[4-[3-[4-chloro-3-(trifluoromethyl)phenyl]-5-(3-hydroxypropyl)-2-oxo-1,3,5-triazinan-1-yl]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
• 化学式: C₂₆H₂₄ClF₄N₅O₄
• 分子量: 581.9
• InChiKey: DTTCMPPPOKBLDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  98.2
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• 2-OXO-1,3,5-PERHYDROTRIAZAPINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE, ANGIOGENESIS, AND INFLAMMATRORY DISORDERS
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP1599466A2

  公开（公告）日：2005-11-30
• 2-Oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders
  申请人：Boyer Stephen

  公开号：US20050032798A1

  公开（公告）日：2005-02-10

  This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
• US7928227B2
  申请人：——

  公开号：US7928227B2

  公开（公告）日：2011-04-19
• [EN] 2-OXO-1,3,5-PERHYDROTRIAZAPINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE, ANGIOGENESIS, AND INFLAMMATRORY DISORDERS<br/>[FR] DERIVES DE 2-OXO-1,3,5-PERHYDROTRIAZAPINE DESTINES AU TRAITEMENT DE MALADIES HYPERPROLIFERATIVES, ANGIOGENIQUES ET INFLAMMATOIRES
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2004078746A2

  公开（公告）日：2004-09-16

  This invention relates to novel diaryl ureas of formula (I), pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.