3-(p-hydroxyphenyl)-propionylphenylalanine methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(p-hydroxyphenyl)-propionylphenylalanine methyl ester
• 英文别名: 2-[3-(4-hydroxyphenyl)propionylamino]-3-phenyl propionic acid methyl ester；methyl 2-[3-(4-hydroxyphenyl)propanoylamino]-3-phenylpropanoate
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.38
• InChiKey: VKSRNHXARKOPHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(p-hydroxyphenyl)-propionylphenylalanine methyl ester 在 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以78%的产率得到3-(p-hydroxyphenyl)-propionylphenylalanine
  参考文献：
  名称：

  Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising the same

  摘要：

  本发明涉及公式I的酚酸衍生物和用于预防和治疗血脂水平相关疾病的组合物，其中该酚酸衍生物具有降低血脂水平、抑制胆固醇代谢相关酶以及预防和治疗血脂水平相关疾病的优异效果。其中，R1、R2、R3、R4和R5独立地为氢、羟基或C1-C6烷氧基；R6为2R1，氢或乙酰基；Rb为COORd或CH2ORd；Rc为氢、苄基、羟基苄基、咪唑甲基、吲哚甲基、线性或支链C1-C6烷基，或C1-C6烷基取代的羟基、硫醇(SH)、硫甲基(SCH3)、NHRd、CNHNH2、CONH2或COORd；而Rd为氢、甲基、乙基或苄基。

  公开号：

  US20030199566A1
• 作为产物：
  描述：

  对羟基苯丙酸 、 L-苯丙氨酸甲酯 、 1-羟基苯并三唑一水物 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 在 水 、 乙酸乙酯 、 magnesium sulfate 、 silica gel 、 ethyl acetate n-hexane 作用下， 以 N,N-二甲基甲酰胺 、 三乙胺 为溶剂， 反应 18.17h， 以to obtain 1.8 g of the title compound的产率得到3-(p-hydroxyphenyl)-propionylphenylalanine methyl ester
  参考文献：
  名称：

  Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising the same

  摘要：

  本发明涉及公式I的酚酸衍生物及包含该酚酸衍生物的预防和治疗血脂水平相关疾病的组合物。这些化合物具有降低血脂水平、抑制胆固醇代谢相关酶以及预防和治疗血脂水平相关疾病的优异效果。

  公开号：

  US07223793B2

文献信息

• PHENYL-CONTAINING N-ACYL AMINE AND AMINOACID DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, A PHARMACEUTICAL COMPOSITION AND THE USE THEREOF
  申请人：Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises"

  公开号：EP1876169A1

  公开（公告）日：2008-01-09

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.

  本发明涉及作为环氧化酶抑制剂的通式（I）生物胺和氨基酸的新型苯基-N-酰基衍生物，该衍生物具有镇痛和抗炎特性，无副作用，特别是无溃疡性和促痉挛作用，并能增强其他镇痛药的效果，此外还具有抗缺氧、抗抑郁和抗帕金森病作用；以及生物胺的新型和已知苯基-N-酰基衍生物的制备工艺、药物组合物和包含通式（I）化合物的制剂及其用途和治疗方法。
• Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof
  申请人：Nebolsin Vladimir Evgenievich

  公开号：US20090111874A1

  公开（公告）日：2009-04-30

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.
• PHENYL-N-ACYL DERIVATIVES OF AMINES AND AMINO ACIDS, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Obschestvo S Ogranichennoi Otvetstvennostiyu

  公开号：US20130109880A1

  公开（公告）日：2013-05-02

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.
• US7223793B2
  申请人：——

  公开号：US7223793B2

  公开（公告）日：2007-05-29
• US8309766B2
  申请人：——

  公开号：US8309766B2

  公开（公告）日：2012-11-13