1-biphenyl-2-yl-2-methyl-propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-biphenyl-2-yl-2-methyl-propan-1-one
• 英文别名: 1-([1,1'-biphenyl]-2-yl)butan-1-one；2-methyl-1-(2-phenylphenyl)propan-1-one
• 化学式: C₁₆H₁₆O
• 分子量: 224.302
• InChiKey: SGVYTXVLLZZEEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-biphenyl-2-yl-2-methyl-propan-1-one 在 palladium diacetate 、 三氟乙酸 、 silver(l) oxide 作用下， 反应 15.0h， 以94%的产率得到10,10-二甲基菲-9-酮
  参考文献：
  名称：

  Synthesis of Phenanthrone Derivatives from sec-Alkyl Aryl Ketones and Aryl Halides via a Palladium-Catalyzed Dual C−H Bond Activation and Enolate Cyclization

  摘要：

  A palladium-catalyzed chelation-assisted C-H activation of alkyl aryl ketones and their reaction with aryl iodides to afford ortho-arylated products is described. For sec-alkyl aryl ketones, the catalytic reaction proceeds further to give 10,10-dialkylphenanthrone derivatives. A possible reaction mechanism involving directed dual C-H bond activation and enolate cyclization for the formation of 10,10-dialkylphenanthrone derivatives is proposed.

  DOI：

  10.1021/ja1026248
• 作为产物：
  描述：

  碘苯 、 异丁酰苯 在 palladium diacetate 、 三氟乙酸 、 silver(l) oxide 作用下， 反应 20.0h， 生成 1-biphenyl-2-yl-2-methyl-propan-1-one
  参考文献：
  名称：

  Synthesis of Phenanthrone Derivatives from sec-Alkyl Aryl Ketones and Aryl Halides via a Palladium-Catalyzed Dual C−H Bond Activation and Enolate Cyclization

  摘要：

  A palladium-catalyzed chelation-assisted C-H activation of alkyl aryl ketones and their reaction with aryl iodides to afford ortho-arylated products is described. For sec-alkyl aryl ketones, the catalytic reaction proceeds further to give 10,10-dialkylphenanthrone derivatives. A possible reaction mechanism involving directed dual C-H bond activation and enolate cyclization for the formation of 10,10-dialkylphenanthrone derivatives is proposed.

  DOI：

  10.1021/ja1026248

文献信息

• Transition-Metal-Free Intramolecular Carbene Aromatic Substitution/Büchner Reaction: Synthesis of Fluorenes and [6,5,7]Benzo-fused Rings
  作者：Zhenxing Liu、Haocheng Tan、Long Wang、Tianren Fu、Ying Xia、Yan Zhang、Jianbo Wang

  DOI：10.1002/anie.201409982

  日期：2015.3.2

  Intramolecular aromatic substitution and Büchner reaction have been established as powerful methods for the construction of polycyclic compounds. These reactions are traditionally catalyzed by RhII catalysts with α‐diazocarbonyl compounds as the substrates. Herein a transition‐metal‐free intramolecular aromatic substitution/Büchner reaction is presented. These reactions use readily available N‐tosylhydrazones

  分子内芳族取代和Büchner反应已被认为是构建多环化合物的有力方法。传统上，这些反应是由Rh II催化剂以α-重氮羰基化合物为底物催化的。本文介绍了无过渡金属的分子内芳族取代/Büchner反应。这些反应使用现成的N-甲苯磺酰hydr作为重氮化合物的前体，并显示出较宽的底物范围。
• Novel Ethanediamone Hepcidine Antagonists
  申请人：Dürrenberger Franz

  公开号：US20120214798A1

  公开（公告）日：2012-08-23

  The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

  本发明涉及一种新型的肝铁蛋白拮抗剂，其化学式为（I），包括它们的药物组合物以及将其用作药物的用途，特别是用于治疗铁代谢紊乱，如特别是铁缺乏病和贫血等疾病，特别是与慢性炎症性疾病相关的贫血（ACD：慢性疾病性贫血和AI：炎症性贫血）。
• A Ruthenium-Catalyzed Reaction of Aromatic Ketones with Arylboronates:  A New Method for the Arylation of Aromatic Compounds via C−H Bond Cleavage
  作者：Fumitoshi Kakiuchi、Shintaro Kan、Kimitaka Igi、Naoto Chatani、Shinji Murai

  DOI：10.1021/ja029273f

  日期：2003.2.19

  The ruthenium-catalyzed reaction of aromatic ketones with arylboronic acid esters (arylboronates) gave the ortho arylation product. For this coupling reaction, a RuH2(CO)(PPh3)3 complex exhibited the highest catalytic activity among the complexes screened. Several aromatic ketones, for example, acetophenones, acetonaphthone, alpha-tetralone, and benzosuberone, can be used in this coupling reaction

  芳族酮与芳基硼酸酯（芳基硼酸酯）在钌催化下反应得到邻位芳基化产物。对于这种偶联反应，RuH2(CO)(PPh3)3 配合物在筛选的配合物中表现出最高的催化活性。几种芳香酮，例如苯乙酮、乙酰萘、α-四氢萘酮和苯并芴酮，可用于该偶联反应。发现各种含有给电子（OMe 和 NMe2）和吸电子（F 和 CF3）基团的芳基硼酸酯与芳香酮反应生成相应的酰化产物。相应的芳基硼酸可用于该偶联反应，但与使用相应芳基硼酸酯的反应相比，产率略低。
• METHOD FOR PRODUCING CYCLOHEXYL ALKYL KETONES
  申请人：Nishiuchi Junya

  公开号：US20120178970A1

  公开（公告）日：2012-07-12

  Provided is an industrially superior method for producing cyclohexyl alkyl ketones, which solves the problems in process reduction and in disposal of wastes such as metals. An aromatic ketone represented by a formula (1) is nuclear-hydrogenated with pressurized hydrogen and in the presence of a solvent at a temperature of from 20 to 120° C., in the presence of a catalyst that carries from 0.1 to 20% by weight of a ruthenium atom on the carrier, thereby producing a cyclohexyl alkyl ketone represented by a formula (2): provided that, in the formula (2), n indicates an integer of from 1 to 3; R represents a hydroxyl group, a cyclohexyl group, an alkyl group having from 1 to 4 carbon atoms, or an acyl group having from 1 to 4 carbon atoms

  提供了一种在工业上优越的生产环己基烷基酮的方法，解决了在过程减少和处理废物（如金属）方面的问题。通过在20至120°C的温度下，在有溶剂存在的情况下使用加压氢气进行核氢化，存在携带从0.1到20%重量的钌原子的催化剂，从而产生一个由式（2）表示的环己基烷基酮：其中，在式（2）中，n表示1到3之间的整数；R代表一个羟基、一个环己基、一个含有1至4个碳原子的烷基或一个含有1至4个碳原子的酰基。
• Hepatitis C Virus Inhibitors
  申请人：Bachand Carol

  公开号：US20080050336A1

  公开（公告）日：2008-02-28

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本公开涉及化合物、组合物和治疗丙型肝炎病毒（HCV）感染的方法。还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。