3-ethyl-2,2,4-tri-n-propyl-2,3-dihydro-1H-1,5-benzodiazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 3-ethyl-2,2,4-tri-n-propyl-2,3-dihydro-1H-1,5-benzodiazepine
• 英文别名: 3-Ethyl-2,2,4-tripropyl-1,3-dihydro-1,5-benzodiazepine
• 化学式: C₂₀H₃₂N₂
• 分子量: 300.487
• InChiKey: CMAWXYDKOYVHLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-庚酮 、 邻苯二胺 在 Zn(L-proline)₂ aluminum oxide 作用下， 反应 0.05h， 以89%的产率得到3-ethyl-2,2,4-tri-n-propyl-2,3-dihydro-1H-1,5-benzodiazepine
  参考文献：
  名称：

  [(L)Proline]₂Zn Catalysed Synthesis of 1,5‐Benzodiazepine Derivatives Under Solvent‐Free Condition

  摘要：

  This communication demonstrates that a novel Lewis acid complex, Zn[(L)proline](2), catalysed one pot synthesis of 1,5-benzodiazepine derivatives under solvent-free conditions. The efficiency of the catalyst has been examined by conventional method and microwave irradiation technique. 1,5-Benzodiazepine is obtained in moderate to good yield (up to 93%) in all the reactions within a shorter reaction time under microwave irradiation. The recycling ability of the catalyst has also been evaluated. The catalyst is reusable up to five times without appreciable loss of its catalytic activity.

  DOI：

  10.1081/scc-200034752