(3S,5S)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,5S)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-one
• 化学式: C₁₂H₂₀O₁₁
• 分子量: 340.28
• InChiKey: FSICMNGKCHFHGP-ADGDDZBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION (LIGNO)CELLULOSIC MATERIAL
  申请人：EMALFARB Mark

  公开号：US20130280764A1

  公开（公告）日：2013-10-24

  The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma , and Talaromyces , plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.

  本发明涉及改良后的丝状真菌生物，其在将纤维素材料中的复杂碳水化合物转化为简单糖方面具有改进的活性特性，包括属于以下组中选择的真菌生物属：Chrysosporium，Thielavia，Talaromyces，Thermomyces，Thermoascus，Neurospora，Aureobasidium，Filibasidium，Piromyces，Corynascus，Cryplococcus，Acremonium，Tolypocladium，Scytalidium，Schizophyllum，Sporotrichum，Penicillium，Gibberella，Myceliophthora，Mucor，Aspergillus，Fusarium，Humicola，Trichoderma和Talaromyces，以及其无性和有性形态。通过改变编码生产纤维二糖内酯，纤维二糖酸，葡萄糖内酯，葡萄糖酸和相关产物的酶的基因，通过各种突变方法，包括核苷酸替换，插入和删除，从而获得具有改进活性特性的丝状真菌生物，增加从改良生物中获得的酶混合物中的糖化水平。
• Biosensing systems for measurement of lactose
  申请人：Reardon Kenneth F.

  公开号：US10024797B2

  公开（公告）日：2018-07-17

  Herein disclosed are biosensing systems that measure lactose concentration in a solution.

  这里公开的是测量溶液中乳糖浓度的生物传感系统。
• Biological platform for production of commodity chemicals
  申请人：The Regents of the University of California

  公开号：US10358668B2

  公开（公告）日：2019-07-23

  The present disclosure generally relates to biological platforms for the conversion of cellulosic biomass into fuels and chemicals. More specifically, the present disclosure relates to the conversion of cellulosic materials into sugar acids or their salts, which may then be used to produce commodity chemicals. In one aspect, the present disclosure relates to a recombinant host cell including: reduced activity of one or more polypeptides having P-glucosidase activity as compared to a corresponding wild type cell, where each of said one or more polypeptides are encoded by a gene that has at least 80% sequence identity to a gene.

  本公开内容一般涉及将纤维素生物质转化为燃料和化学品的生物平台。更具体地说，本公开涉及将纤维素材料转化为糖酸或其盐，然后可用于生产商品化学品。在一个方面，本公开涉及一种重组宿主细胞，该细胞包括：与相应的野生型细胞相比，具有 P-葡萄糖苷酶活性的一种或多种多肽的活性降低，其中所述的一种或多种多肽中的每一种多肽都由与基因具有至少 80% 序列同一性的基因编码。
• METHODS FOR INCREASING HYDROLYSIS OF CELLULOSIC MATERIAL IN THE PRESENCE OF CELLOBIOSE DEHYDROGENASE
  申请人：Novozymes Inc.

  公开号：EP2379712B1

  公开（公告）日：2017-02-22
• EXTRACELLULAR ALDONOLACTONASE
  申请人：The Regents of the University of California

  公开号：EP2598643A2

  公开（公告）日：2013-06-05