2-amino-5'-chloro-8,8-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-amino-5'-chloro-8,8-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile
• 英文别名: 2'-amino-5-chloro-8',8'-dimethyl-2,5'-dioxospiro[1H-indole-3,4'-6,7-dihydrochromene]-3'-carbonitrile
• 化学式: C₁₉H₁₆ClN₃O₃
• 分子量: 369.807
• InChiKey: DKITVHDGVDZOJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氯靛红 、 5,5-二甲基-1,3-环己二酮 、 丙二腈 在 [Ch-OSO3H]₃W₁₂PO₄₀ 作用下， 以 乙醇 为溶剂， 反应 0.75h， 以89%的产率得到2-amino-5'-chloro-8,8-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile
  参考文献：
  名称：

  An efficient approach for the synthesis of spirooxindole derivatives catalyzed by novel sulfated choline based heteropolyanion at room temperature

  摘要：

  A new zwitterionic salt, sulfated choline based heteropolyanion, which was reported earlier by our group, has been found to be very effective for the synthesis of spirooxindole derivatives at room temperature. The heteropolyanion based on sulfated ionic liquid (HIL) showed promising features for the reaction, such as shorter reaction time, high product yields (about 90-95%), simple work up, easy removal, and reusability of the catalyst for several times without significant loss in its efficiency. This has made the protocol sustainable and economic. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.06.050

文献信息

• An efficient approach for the synthesis of spirooxindole derivatives catalyzed by novel sulfated choline based heteropolyanion at room temperature
  作者：Shailesh P. Satasia、Piyush N. Kalaria、Jemin R. Avalani、Dipak K. Raval

  DOI：10.1016/j.tet.2014.06.050

  日期：2014.9

  A new zwitterionic salt, sulfated choline based heteropolyanion, which was reported earlier by our group, has been found to be very effective for the synthesis of spirooxindole derivatives at room temperature. The heteropolyanion based on sulfated ionic liquid (HIL) showed promising features for the reaction, such as shorter reaction time, high product yields (about 90-95%), simple work up, easy removal, and reusability of the catalyst for several times without significant loss in its efficiency. This has made the protocol sustainable and economic. (C) 2014 Elsevier Ltd. All rights reserved.