(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
• 化学式: C₁₈H₃₆N₄O₁₁
• 分子量: 484.5
• InChiKey: SBUJHOSQTJFQJX-BTALVITBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  283
• 氢给体数：
  11
• 氢受体数：
  15

文献信息

• AMINOGLYCOSIDE DOSING REGIMENS
  申请人：Bruss Jon B.

  公开号：US20120208781A1

  公开（公告）日：2012-08-16

  The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.

  本发明提供了新的氨基糖苷类药物给药方案，与增强微生物杀灭活性和降低肾毒性有关，并提供了使用这些给药方案治疗各种细菌感染的方法。
• ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
  申请人：Goldblum Adam Aaron

  公开号：US20120135948A1

  公开（公告）日：2012-05-31

  Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 1 , R 2 and R 3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本发明揭示了具有抗菌活性的化合物。该化合物具有以下结构（I）或（II）：包括立体异构体、药学上可接受的盐和前药，其中Q1、Q2、Q3、R1、R2和R3的定义如本文所述。本发明还揭示了与制备和使用此类化合物相关的方法，以及包含此类化合物的制药组合物。
• US8524689B2
  申请人：——

  公开号：US8524689B2

  公开（公告）日：2013-09-03
• [EN] AMINOGLYCOSIDE DOSING REGIMENS<br/>[FR] SCHÉMAS POSOLOGIQUES D'AMINOGLYCOSIDE
  申请人：ACHAOGEN INC

  公开号：WO2010132839A2

  公开（公告）日：2010-11-18

  The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.
• [EN] ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS<br/>[FR] ANALOGUES D'AMINOGLYCOSIDE ANTIBACTÉRIENS
  申请人：ACHAOGEN INC

  公开号：WO2010132757A2

  公开（公告）日：2010-11-18

  Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.