sodium;(3S)-N-[(3R,4R,5S,6R)-2-hydroxy-6-(hydroxymethyl)-4-(9-phenylnonanoyloxy)-5-sulfooxyoxan-3-yl]-3-(9-phenylnonanoyloxy)tetradecanimidate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sodium;(3S)-N-[(3R,4R,5S,6R)-2-hydroxy-6-(hydroxymethyl)-4-(9-phenylnonanoyloxy)-5-sulfooxyoxan-3-yl]-3-(9-phenylnonanoyloxy)tetradecanimidate
• 化学式: C50H78NNaO12S
• 分子量: 940.2
• InChiKey: KSLCVWMGAOQHEA-TZBBHZOSSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  6.11
• 重原子数：
  65
• 可旋转键数：
  37
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  206
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• GLUCOPYRANOSE DERIVATIVES AND PREVENTIVES AND/OR REMEDIES FOR HIV INFECTION CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1095653A9

  公开（公告）日：2002-04-03

  The present invention relates to a medicament for preventing and / or treating HIV infectious diseases comprising a compound of formula (J) as active ingredient and glucopyranose derivative of formula (W) or non-toxic salts thereof (the symbols in the formula are as described in the specification).A glucopyranose derivative of formulae (J) or (W) or a non-toxic salt thereof is useful as a medicament for preventing and / or treating HIV infectious diseases (AIDS).

  本发明涉及一种预防和/或治疗HIV感染疾病的药物，其包括公式（J）化合物作为活性成分和公式（W）的葡萄糖吡喃糖衍生物或其非毒性盐（公式中的符号如规范中所述）。公式（J）或（W）的葡萄糖吡喃糖衍生物或其非毒性盐可用作预防和/或治疗HIV感染疾病（艾滋病）的药物。
• IMMUNOSUPPRESSANT CONTAINING GLUCOPYRANOSE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1088553A1

  公开（公告）日：2001-04-04

  An immunosuppressant comprising Glucopyranose derivatives of the formula (I): wherein R is H, OH etc; G is ―CH2CH(R1-R2)(R3-R4), in which R1 is a single bond, OCO-alkyl ; R2, R4 is H, phenyl which may be substituted by halogen atoms etc.; R3 is alkylene ; R5 is OCO-alkyl, R6 is H, phenyl which may be substituted by halogen atoms etc. or R5-R6 is OCO-Z-(dialkoxyphenyl); R7 is H, CH2OH etc; or non-toxic salts thereof as active ingredient. Glucopyranose derivatives of the formula (I) or non-toxic salts thereof possess an activity of immunosuppression, and being useful as the prevention and/or treatment of diseases caused by abnormal enhancement of immunity, e.g. allergic diseases, autoimmune diseases.

  一种由式(I)的吡喃葡萄糖衍生物组成的免疫抑制剂： 其中R是H、OH等；G是-CH2CH(R1-R2)(R3-R4)，其中R1是单键、OCO-烷基；R2、R4是H、可被卤素原子取代的苯基等；R3是亚烷基；R5是OCO-烷基，R6是H、可被卤素原子取代的苯基等，或R5-R6是OCO-Z-(二烷氧基苯基)；R7是H、CH2OH等；或其作为活性成分的无毒盐。 式（I）的吡喃葡萄糖衍生物或其无毒盐具有免疫抑制活性，可用于预防和/或治疗因免疫异常增强而引起的疾病，如过敏性疾病、自身免疫性疾病。
• Salts of glucopyranose derivative and its intermediate
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0553786B1

  公开（公告）日：2002-04-17
• JPH0641175A
  申请人：——

  公开号：JPH0641175A

  公开（公告）日：1994-02-15
• Glucopyranose derivatives and medicaments for preventing and/or treating HIV infection diseases comprising the same as an active ingredient
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20040072767A1

  公开（公告）日：2004-04-15

  The present invention relates to a medicament for preventing and/or treating HIV infectious diseases comprising a compound of formula (J) as active ingredient and glucopyranose derivative of formula (W) or non-toxic salts thereof (the symbols in the formula are as described in the specification). A glucopyranose derivative of formulae (J) or (W) or a non-toxic salt thereof is useful as a medicament for preventing and/or treating HIV infectious disease (AIDS). 1