5-tert-butyl 1-methyl glutamate hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-tert-butyl 1-methyl glutamate hydrochloride
• 英文别名: Glu(Boc)-OMe hydrochloride；5-Tert-butyl 1-methyl 2-aminopentanedioate hydrochloride；5-O-tert-butyl 1-O-methyl 2-aminopentanedioate;hydrochloride
• 化学式: C₁₀H₁₉NO₄*ClH
• 分子量: 253.726
• InChiKey: YIFPACFSZQWAQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.27
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  78.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-tert-butyl 1-methyl glutamate hydrochloride 在 N-甲基吗啉 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 二乙胺 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.5h， 生成 di-tert-butyl 3,3'-((2S,5S)-3,6-dioxopiperazine-2,5-diyl)dipropionate
  参考文献：
  名称：

  Melanocortin receptor-specific compounds

  摘要：

  一种具有结构I：1的一般式的黑素皮质素受体特异性化合物，其中X、R1、R2a、R2b、R3、R4a、R4b、R5a和R5b如说明书中所定义，该化合物与一个或多个黑素皮质素受体高亲和结合，并可选择性地为激动剂、拮抗剂、逆拮抗剂或逆拮抗剂的拮抗剂，并可用于治疗一个或多个黑素皮质素受体相关疾病或疾病，并且使用该发明化合物的方法。

  公开号：

  US20040224957A1

文献信息

• [EN] COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY<br/>[FR] COMPOSÉS ET PROCÉDÉS DE TRAITEMENT ANTICANCÉREUX PAR L'INHIBITION D'ATG4B ET LE BLOCAGE DE L'AUTOPHAGIE
  申请人：UNIV FRASER SIMON

  公开号：WO2017027984A1

  公开（公告）日：2017-02-23

  ATG4B inhibitor compounds, compositions that include the compounds, and methods for using the compounds and compositions in the treatment of cancer by inhibiting ATG4B and/or blocking autophagy.

  ATG4B抑制剂化合物，包括该化合物的组合物，以及使用该化合物和组合物在治疗癌症中通过抑制ATG4B和/或阻断自噬的方法。
• [EN] SYNTHETIC LIPOAMINO ACID GLUCOSAMINE DERIVATIVES FOR IMPROVEMENT OF PLANT GROWTH AND YIELD<br/>[FR] DÉRIVÉS DE LIPO-AMINOACIDE-GLUCOSAMINE SYNTHÉTIQUES POUR AMÉLIORATION DE LA CROISSANCE ET DU RENDEMENT DE PLANTE
  申请人：DU PONT

  公开号：WO2014143620A1

  公开（公告）日：2014-09-18

  The invention provides compounds, formulations and methods for improving plant emergence, growth and yield. More specifically, the present invention relates to compositions comprising the synthetic lipoamino acid glucosamine compounds of Formula 1 below wherein the substituents are as defined in the claims. These compounds may be applied to plant propagating materials, including seeds and other regenerable plant parts, including cuttings, bulbs, rhizomes and tubers. They may also be applied to foliage, or soil either prior to or following planting of plant propagating materials. Such applications may be made alone or in combination with fungicides, insecticides, nematicides and other agricultural agents used to improve plant growth and crop yield. The compounds of Formula I can improve the agronomic performance of a variety of crops including barley, canola, corn, potato, soybean and wheat.

  该发明提供了用于改善植物出苗、生长和产量的化合物、配方和方法。更具体地说，本发明涉及包含以下化学式1中的合成脂氨基酸葡萄糖胺化合物的组合物，其中取代基如权利要求中定义的那样。这些化合物可应用于植物繁殖材料，包括种子和其他可再生植物部分，包括插枝、球茎、根茎和块茎。它们也可以应用于叶片或土壤，无论是在植物繁殖材料种植之前还是之后。这些应用可以单独进行，也可以与杀菌剂、杀虫剂、线虫杀灭剂和其他用于改善植物生长和作物产量的农业药剂结合使用。化合物I的公式可以改善多种作物的农艺性能，包括大麦、油菜、玉米、马铃薯、大豆和小麦。
• LIGAND-THERAPEUTIC AGENT CONJUGATES, SILICON-BASED LINKERS, AND METHODS FOR MAKING AND USING THEM
  申请人：Albany Molecular Research, Inc.

  公开号：US20160235858A1

  公开（公告）日：2016-08-18

  The present invention relates to ligand-therapeutic agent conjugate compounds, silicon linkers for the conjugate compounds, compositions, methods for making them, and methods for the treatment of cancer using the conjugate compounds. The silicon-based linkers described herein can be used to deliver desired therapeutic agents to particular cells or tissue types targeted by the ligand.

  本发明涉及配体-治疗剂结合物化合物、用于配体-治疗剂结合物的硅连接剂、组合物、制造它们的方法，以及使用配体-治疗剂结合物治疗癌症的方法。本文所描述的基于硅的连接剂可用于将所需的治疗剂递送到配体所针对的特定细胞或组织类型。
• SYNTHETIC LIPOAMINO ACID GLUCOSAMINE DERIVATIVES FOR IMPROVEMENT OF PLANT GROWTH AND YIELD
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：US20160021879A1

  公开（公告）日：2016-01-28

  The invention provides compounds, formulations and methods for improving plant emergence, growth and yield. More specifically, the present invention relates to compositions comprising the synthetic lipoamino acid glucosamine compounds of Formula I. These compounds may be applied to plant propagating materials, including seeds and other regenerable plant parts, including cuttings, bulbs, rhizomes and tubers. They may also be applied to foliage, or soil either prior to or following planting of plant propagating materials. Such applications may be made alone or in combination with fungicides, insecticides, nematicides and other agricultural agents used to improve plant growth and crop yield. The compounds of Formula I can improve the agronomic performance of a variety of crops including barley, canola, corn, potato, soybean and wheat.

  本发明提供了用于改善植物出苗、生长和产量的化合物、配方和方法。更具体地说，本发明涉及包含化学合成的脂肽氨基糖化合物（公式I）的组合物。这些化合物可以应用于植物繁殖材料，包括种子和其他可再生植物部分，包括插条、鳞茎、根茎和块茎。它们也可以应用于叶片或土壤，无论是在种植植物繁殖材料之前还是之后。这种应用可以单独进行，也可以与杀菌剂、杀虫剂、线虫灭生剂和其他用于改善植物生长和作物产量的农业剂一起使用。公式I的化合物可以改善各种作物的农艺性能，包括大麦、油菜、玉米、马铃薯、大豆和小麦。
• Decapitation of a 5' capped RNA by an antisense copper complex conjugate
  作者：Brenda F. Baker、Kanda Ramasamy、John Kiely

  DOI：10.1016/0960-894x(96)00295-8

  日期：1996.7

  This report presents the synthesis and 5' cap reactivity of an antisense oligodeoxynucleotide equipped with two equivalents of an analog of N-(2-mercaptopropionyl)glycine (MPG). MPG is a peptide derivative which coordinates to copper(II) in solution as a monomeric species via the thiol, amide, and carboxylate groups. Decapitation of a complementary 5' capped RNA was observed for the oligonucleotide-ligand conjugate coordinated to copper. Copyright (C) 1996 Elsevier Science Ltd