dimethyl 1,3-phenylene-bis(5,7-dimethoxyindol-1-ylmethyl-2-carboxylate)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: dimethyl 1,3-phenylene-bis(5,7-dimethoxyindol-1-ylmethyl-2-carboxylate)
• 英文别名: Methyl 1-[[3-[(5,7-dimethoxy-2-methoxycarbonylindol-1-yl)methyl]phenyl]methyl]-5,7-dimethoxyindole-2-carboxylate；methyl 1-[[3-[(5,7-dimethoxy-2-methoxycarbonylindol-1-yl)methyl]phenyl]methyl]-5,7-dimethoxyindole-2-carboxylate
• 化学式: C₃₂H₃₂N₂O₈
• 分子量: 572.615
• InChiKey: JCRSVJSJEHHJDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99.4
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  methyl 2-azido-3-(3,5-dimethoxyphenyl)propeonate 在 氢氧化钾 作用下， 以 二甲基亚砜 、 邻二氯苯 为溶剂， 反应 26.0h， 生成 dimethyl 1,3-phenylene-bis(5,7-dimethoxyindol-1-ylmethyl-2-carboxylate)
  参考文献：
  名称：

  Regioselective reactivity of some 5,7-dimethoxyindoles

  摘要：

  The reactivity of some 5,7-dimethoxyindoles with respect to electrophiles has been investigated. The favoured sites for reaction are C3 and C4 and regioselectivity can be controlled by the judicious arrangement of electron-withdrawing substituents. Results of formylation, acylation, the Mannich reaction, bromination and nitration are described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.048

文献信息

• Regioselective reactivity of some 5,7-dimethoxyindoles
  作者：Glenn C. Condie、Michelle F. Channon、Andrew J. Ivory、Naresh Kumar、David StC. Black

  DOI：10.1016/j.tet.2005.03.048

  日期：2005.5

  The reactivity of some 5,7-dimethoxyindoles with respect to electrophiles has been investigated. The favoured sites for reaction are C3 and C4 and regioselectivity can be controlled by the judicious arrangement of electron-withdrawing substituents. Results of formylation, acylation, the Mannich reaction, bromination and nitration are described. (c) 2005 Elsevier Ltd. All rights reserved.