5-benzoyl-6-phenyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-benzoyl-6-phenyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
• 英文别名: 5-benzoyl-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one
• 化学式: C₁₇H₁₂N₂O₂S
• 分子量: 308.4
• InChiKey: WERLYHHYBGZNQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2
  申请人：BILOUSOVA Tina

  公开号：US20200270216A1

  公开（公告）日：2020-08-27

  Provided herein are compounds of Formula (I) and (II) and their salts, and compositions comprising such compounds that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) in cells. Also disclosed herein are methods of using the disclosed compounds and compositions for inhibiting the spread of Tau seeds from donor cells to recipient cells. Moreover, disclosed herein are methods of using the disclosed compounds and compositions for treating or preventing a neurodegenerative disorder, such as a tauopathy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).