Boc-Gly-PAM resin

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Gly-PAM resin
• 英文别名: [1-[(2S)-2,6-diaminohexanoyl]pyrrolidin-3-yl] benzoate;2,2,2-trifluoroacetic acid
• 化学式: C₇H₁₂NO₄Pol
• 分子量: 433.4
• InChiKey: YLNQSMUMQDRKBF-SCYKNNLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Boc-Gly-PAM resin 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.5h， 生成 2-chlorotrityl resin
  参考文献：
  名称：

  FUNGICIDES

  摘要：

  公开号：

  EP1204323B1
• 作为产物：
  描述：

  (S)-2,6-二叔丁氧羰基氨基己酸 在 吡啶 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 Boc-Gly-PAM resin
  参考文献：
  名称：

  Design, Synthesis, and SAR of Potent and Selective Dipeptide-Derived Inhibitors for Dipeptidyl Peptidases

  摘要：

  In this paper we report the systematic search for new, potent, and selective DPP II inhibitors. A study of the structure-activity relationship was conducted starting from aminoacyl pyrrolidides as lead compounds. Rational exploration of the P-1 and P-2 building blocks led to the discovery of some very potent DPP II inhibitors which can be characterized by their high selectivity for DPP II with regard to DPP IV. Dab-Pip and Dab-Pip-2-CN were selected as the most promising inhibitors (IC50 nM range) and will enable us to study the physiological role of DPP II and to differentiate between DPP 11 and DPP IV in biological systems.

  DOI：

  10.1021/jm0308803

文献信息

• TETRAZINES/TRANS-CYCLOOCTENES IN SOLID PHASE SYNTHESIS OF LABELED PEPTIDES
  申请人：MEMORIAL SLOAN-KETTERING CANCER CENTER

  公开号：US20150359913A1

  公开（公告）日：2015-12-17

  This invention is in the field of labeled peptide construction for medical treatment and analysis. The invention relates to synthetic labeled peptide compositions, methods of synthesis, and methods of use for the synthetic labeled peptide compositions for medical treatment, imaging, and research purposes.

  这项发明涉及用于医疗治疗和分析的标记肽构建领域。该发明涉及合成标记肽组合物、合成方法以及用于医疗治疗、成像和研究目的的合成标记肽组合物的使用方法。
• Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter
  作者：Andreas Brust、Ching-I. A. Wang、Norelle L. Daly、Joe Kennerly、Mahsa Sadeghi、Macdonald J. Christie、Richard J. Lewis、Mehdi Mobli、Paul F. Alewood

  DOI：10.1002/anie.201304660

  日期：2013.11.11

  Loopy peptides: Peptide turn mimetics of a clinically relevant norepinephrine reuptake inhibitor were developed employing a high‐throughput synthesis approach to generate peptide thioesters, with subsequent cyclization through native chemical ligation. The vicinal disulfide constrained cyclic peptidomimetics (see scheme) show high structural and functional similarity to the parent peptide, though with

  环状肽：使用高通量合成方法开发临床相关的去甲肾上腺素再摄取抑制剂的肽转模拟物，以生成肽硫酯，随后通过天然化学连接进行环化。邻二硫化物约束的环状拟肽（见方案）显示出与亲本肽高度的结构和功能相似性，尽管具有优异的代谢稳定性。
• [EN] DIPEPTIDYL PEPTIDASE INHIBITORS<br/>[FR] INHIBITEURS DE DIPEPTIDYLE PEPTIDASE
  申请人：AIC

  公开号：WO2004076433A1

  公开（公告）日：2004-09-10

  The present invention relates to novel inhibitors of serine type peptidases in general and of serine type dipeptidyl peptidases in particular. The present invention further relates to the use of the dipeptidyl peptidase inhibitors for selective inhibition of dipeptidyl peptidases. The present invention also relates to pharmaceutical compositions comprising these novel dipeptidyl peptidase inhibitors. The present invention further relates to the use of the novel inhibitors in therapy, diagnosis and research.

  本发明涉及一般性的新型丝氨酸型肽酶抑制剂，特别是丝氨酸型二肽基肽酶的抑制剂。本发明还涉及利用二肽基肽酶抑制剂对二肽基肽酶进行选择性抑制。本发明还涉及包含这些新型二肽基肽酶抑制剂的药物组合物。本发明还涉及在治疗、诊断和研究中使用这些新型抑制剂。
• Growth Hormones with Prolonged In-Vivo Efficacy
  申请人：Novo Nordisk HealthCare AG

  公开号：US20180221501A1

  公开（公告）日：2018-08-09

  The present invention relates to polypeptide compound optimized for subcutaneous administration, exemplified by growth hormone conjugates having a linker providing non-covalent binding to albumin.

  本发明涉及优化了亚皮下注射的多肽化合物，例如具有连接剂的生长激素偶联物，该连接剂提供与白蛋白的非共价结合。
• WO2006/82392
  申请人：——

  公开号：——

  公开（公告）日：——