3-methylheptane-1,3-diol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-methylheptane-1,3-diol
• 化学式: C₈H₁₈O₂
• 分子量: 146.23
• InChiKey: MEJJUZUMTCTDCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methylheptane-1,3-diol 在 4-二甲氨基吡啶 、 sodium azide 、 cesium hydroxide 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 30.08h， 生成 C₁₀H₁₆N₃O₄^(1-)*Cs⁽¹⁺⁾
  参考文献：
  名称：

  银催化草酸铯的自由基催化脱羧氟化合成烷基氟

  摘要：

  草酸铯很容易从醇中获得，在银盐催化剂和Selectfluor®存在下进行自由基脱氧氟化反应，生成烷基氟化物。在此，描述了氟化方案的范围和简要的机理研究。

  DOI：

  10.1002/ejoc.202100344
• 作为产物：
  描述：

  Ethyl 3-hydroxy-3-methylheptanoate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.58h， 生成 3-methylheptane-1,3-diol
  参考文献：
  名称：

  Synthesis and evaluation of a potent, well-balanced EP 2 /EP 3 dual agonist

  摘要：

  A highly potent and well-balanced dual agonist for the EP2 and EP3 receptors is described. Optimization of the lead compound was accomplished in consideration of the relative agonist activity against each EP subtype receptor and the pharmacokinetic profile. As the result, 2-[(2-{(1R,2R)-2-[(1E,4S)-5-cyclopentyl-4-hydroxy-4-methyl-1-penten-1-yl]-5-oxocyclopentyl}eth-yl)thio]-1,3-thiazole-4-carboxylic acid (10) showed excellent potency (human EC50 EP2 = 1.1 nM, EP3 = 1.0 nM) with acceptable selectivity over the EP1 and EP4 subtypes (> 2000-fold). Further fine-tuning of compound 10 led to identification of ONO-8055 as a clinical candidate. ONO-8055 was effective at an extremely low dose (0.01 mg/kg, po, bid) in rats, and dose-dependently improved voiding dysfunction in a monkey model of underactive bladder (UAB). ONO-8055 is expected to be a novel and highly promising drug for UAB. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2017.11.035

文献信息

• CROSS-LINKED UNSATURATED POLYCARBONATE RESINS
  申请人：UBE Corporation Europe, S.A.U.

  公开号：EP3106486A1

  公开（公告）日：2016-12-21

  The invention concerns cross-linked unsaturated polycarbonate resins having repeating units with the structures: and These cross-linked unsaturated polycarbonate resins display an improved flexibility compared to the corresponding polyester resins.

  本发明涉及具有以下结构重复单元的交联不饱和聚碳酸酯树脂： 和 与相应的聚酯树脂相比，这些交联不饱和聚碳酸酯树脂具有更好的柔韧性。
• Patterning process
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US11366386B2

  公开（公告）日：2022-06-21

  A patterning process, including: forming the first resist film from first resist material containing an acid generator and thermosetting compound having a hydroxy group and/or carboxy group protected by an acid-labile group; forming the second resist film on first resist film from a second resist material containing a metal compound (A) and a sensitizer; irradiating the first and second resist film with a high energy beam or an electron beam to perform pattern exposure to deprotect the hydroxy group and/or carboxy group in a pattern exposed portion of first resist film and to form a crosslinked portion of the component (A) with the deprotected hydroxy and/or carboxy group on the pattern exposed portion; and developing the second resist film with a developer to give a metal film pattern composed of the crosslinked portion. This provides a method for forming a thin film resist pattern with higher resolution and higher sensitivity.

  一种图形化方法，包括以下步骤： 1. 形成第一抗蚀膜：使用包含酸发生剂及具有被酸敏感基团保护的羟基和/或羧基的热固性化合物的第一抗蚀材料。 2. 形成第二抗蚀膜：在第一抗蚀膜上使用包含金属化合物(A)和感光剂的第二抗蚀材料。 3. 曝光：利用高能束或电子束照射第一和第二抗蚀膜，进行图形曝光。在此过程中，暴露区域的第一抗蚀膜中的羟基和/或羧基的保护基团被去除，同时金属化合物(A)与脱保护的羟基和/或羧基在该暴露区域形成交联部分。 4. 显影：使用显影剂显影第二抗蚀膜，形成由交联部分构成的金属膜图案。 此方法能够实现更高分辨率和更高灵敏度的薄膜抗蚀图形制备。
• CONCENTRATED, WATER DISPERSIBLE, STABLE, FABRIC SOFTENING COMPOSITIONS
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0839179A1

  公开（公告）日：1998-05-06
• CONCENTRATED, STABLE FABRIC SOFTENING COMPOSITIONS INCLUDING CHELANTS
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0839180A1

  公开（公告）日：1998-05-06
• CONCENTRATED, STABLE FABRIC SOFTENING COMPOSITION
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0842250A1

  公开（公告）日：1998-05-20