吲哚-2,6-二甲酸二甲酯 | 881040-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 吲哚-2,6-二甲酸二甲酯
• 中文别名: 吲哚-2,6-二甲酸甲酯；2,6-二甲酯1H-吲哚-2,6-二羧酸；2-甲氧羰基-6-甲氧羰基吲哚
• 英文名称: 1H-indole-2,6-dicarboxylic acid dimethyl ester
• 英文别名: dimethyl 1H-indole-2,6-dicarboxylate
• CAS: 881040-29-5
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.224
• InChiKey: WBAMUOTUHSKBPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险性防范说明：
  P280
• 危险性描述：
  H302,H317

反应信息

• 作为产物：
  描述：

  (Z)-methyl 4-(2-bromo-3-methoxy-3-oxoprop-1-enyl)-3-nitrobenzoate 在 三乙烯二胺 、 copper(l) iodide 、 铁粉 、 potassium carbonate 、 溶剂黄146 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 5.08h， 生成 吲哚-2,6-二甲酸二甲酯
  参考文献：
  名称：

  CuI-catalyzed intramolecular cyclization of 3-(2-aminophenyl)-2-bromoacrylate: synthesis of 2-carboxyindoles

  摘要：

  A new approach was described for the synthesis of substituted 2-carboxyindole using 3-(2-aminophenyl)-2-bromo-acrylates through a CuI-catalyzed intramolecular coupling. The reactions were mild, rapid and with good to excellent yields. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.10.048

文献信息

• Copolymer compound and electrochemical cell therewith
  申请人：Takahashi Naoki

  公开号：US20050178659A1

  公开（公告）日：2005-08-18

  The present invention relates to a copolymer compound prepared by copolymerizing two or more monomers selected from indole and indole derivatives. The copolymer compound can be used as an electrode active material to provide an electrochemical cell with an increased capacity and improved cycle properties.

  本发明涉及一种通过共聚选自吲哚和吲哚衍生物的两种或两种以上单体而制备的共聚物化合物。该共聚物化合物可用作电极活性材料，使电化学电池具有更高的容量和更好的循环性能。
• Tandem Palladium-Catalyzed N,C-Coupling/Carbonylation Sequence for the Synthesis of 2-Carboxyindoles
  作者：Tiago O. Vieira、Laura A. Meaney、Yong-Ling Shi、Howard Alper

  DOI：10.1021/ol801985q

  日期：2008.11.6

  Tandem palladium-catalyzed N,C-coupling/carbonylation, under 10 atm of carbon monoxide and at 110 degrees C, is a novel and efficient method for the preparation of 2-carboxyindoles. The catalyst system tolerates a variety of functional groups, and the noted indoles were obtained in good isolated yields.
• CuI-catalyzed intramolecular cyclization of 3-(2-aminophenyl)-2-bromoacrylate: synthesis of 2-carboxyindoles
  作者：Xiong Xiao、Tian-Qi Chen、Jiangmeng Ren、Wei-Dong Chen、Bu-Bing Zeng

  DOI：10.1016/j.tetlet.2013.10.048

  日期：2014.3

  A new approach was described for the synthesis of substituted 2-carboxyindole using 3-(2-aminophenyl)-2-bromo-acrylates through a CuI-catalyzed intramolecular coupling. The reactions were mild, rapid and with good to excellent yields. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.