5-<2,3-dihydro-2-oxo-1-phenyl-3-(4-pyridinylmethyl)-1H-indol-3-yl>-2-pentanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-<2,3-dihydro-2-oxo-1-phenyl-3-(4-pyridinylmethyl)-1H-indol-3-yl>-2-pentanone
• 英文别名: 3-(4-Oxopentyl)-1-phenyl-3-(pyridin-4-ylmethyl)indol-2-one
• 化学式: C₂₅H₂₄N₂O₂
• 分子量: 384.478
• InChiKey: SOXOUHNJXOHJIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氯-2-戊酮 在 盐酸 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 32.0h， 生成 5-<2,3-dihydro-2-oxo-1-phenyl-3-(4-pyridinylmethyl)-1H-indol-3-yl>-2-pentanone
  参考文献：
  名称：

  3-Substituted 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H-indol-2-ones as acetylcholine release enhancers: synthesis and SAR

  摘要：

  A series of 3-substituted, 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H-indol-2-ones was synthesized and found to enhance the stimulus-induced release of neurotransmitter acetylcholine (AcCh), and by doing so, might be useful in treating cognitive disorders where the level of this neurotransmitter may be diminished in the brain, as in Alzheimer's disease. An attempt has been made to correlate the structure of the 3-substitution with the ability of the compounds to enhance the release of AcCh from the striatum region of rat brain preparations.

  DOI：

  10.1021/jm00072a009

文献信息

• 3-Substituted 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H-indol-2-ones as acetylcholine release enhancers: synthesis and SAR
  作者：Wendell W. Wilkerson、Ahmed A. Kergaye、S. William Tam

  DOI：10.1021/jm00072a009

  日期：1993.10

  A series of 3-substituted, 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H-indol-2-ones was synthesized and found to enhance the stimulus-induced release of neurotransmitter acetylcholine (AcCh), and by doing so, might be useful in treating cognitive disorders where the level of this neurotransmitter may be diminished in the brain, as in Alzheimer's disease. An attempt has been made to correlate the structure of the 3-substitution with the ability of the compounds to enhance the release of AcCh from the striatum region of rat brain preparations.