(E)-5-bromo-3-(2-oxo-1-((2-oxo-2-phenylethyl)thio)-2-phenylethylidene)indolin-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-5-bromo-3-(2-oxo-1-((2-oxo-2-phenylethyl)thio)-2-phenylethylidene)indolin-2-one
• 英文别名: (3E)-5-bromo-3-(2-oxo-1-phenacylsulfanyl-2-phenylethylidene)-1H-indol-2-one
• 化学式: C₂₄H₁₆BrNO₃S
• 分子量: 478.366
• InChiKey: FUCYCPFMYRCKTO-XTQSDGFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.61
• 重原子数：
  30.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  63.24
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  5-溴靛红 、 苯乙酰基硫氰酸酯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以79%的产率得到(E)-5-bromo-3-(2-oxo-1-((2-oxo-2-phenylethyl)thio)-2-phenylethylidene)indolin-2-one
  参考文献：
  名称：

  Efficient three-component reactions of α-thiocyanato ketones stereoselectively forming E-3-aroylidene-2-oxindole derivatives

  摘要：

  A new three-component reaction of cc-thiocyanato ketones under microwave irradiation for the stereo-selective synthesis of 25 examples of E-3-aroylidene-2-oxindole derivatives has been described. The domino reaction simultaneously installs C-S and C-C bonds through continuous [3+2] cycloaddition/ring opening of in situ generated 1,3-oxathiolanes/S(N)2-type reaction sequence. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.10.151

文献信息

• Efficient three-component reactions of α-thiocyanato ketones stereoselectively forming E-3-aroylidene-2-oxindole derivatives
  作者：Xue Wang、Qiong Wu、Bo Jiang、Wei Fan、Shu-Jiang Tu

  DOI：10.1016/j.tetlet.2013.10.151

  日期：2014.1

  A new three-component reaction of cc-thiocyanato ketones under microwave irradiation for the stereo-selective synthesis of 25 examples of E-3-aroylidene-2-oxindole derivatives has been described. The domino reaction simultaneously installs C-S and C-C bonds through continuous [3+2] cycloaddition/ring opening of in situ generated 1,3-oxathiolanes/S(N)2-type reaction sequence. (C) 2013 Elsevier Ltd. All rights reserved.