2H-5,6-diethylpyranone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2H-5,6-diethylpyranone
• 英文别名: 5,6-Diethyl-2-pyrone；5,6-diethylpyran-2-one
• 化学式: C₉H₁₂O₂
• 分子量: 152.193
• InChiKey: FBMKUSHJQQZAGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-己炔 、 (Z)-3-碘丙烯酸甲酯 在 bis(triphenylphosphine)nickel(II) chloride 、 锌 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以50%的产率得到2H-5,6-diethylpyranone
  参考文献：
  名称：

  Halogen-dependent coupling reaction of alkynes with (Z)-3-halopropenoates catalyzed by nickel

  摘要：

  Ni-catalyzed coupling reaction of alkynes with (Z)-3-halopropenoates depended on the halogen of halopropenoates. The reaction with (Z)-3-bromopropenoate afforded cyclopentadienes and the reaction with Q-3-iodopropenoates gave pyrones. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00182-9

文献信息

• Rhodium(III)-Catalyzed Oxidative Annulation of Acrylic Acid with Alkynes: An Easy Approach to the Synthesis of α-Pyrones
  作者：Yu-Ting Li、Yan Zhu、Guang-Liang Tu、Jing-Yu Zhang、Ying-Sheng Zhao

  DOI：10.1002/asia.201801190

  日期：2018.11.2

  A highly efficient rhodium(III)‐catalyzed direct oxidative annulation of acrylic acid with alkynes to form α‐pyrones was developed. Various substituted acrylic acids were compatible in this transformation, affording the corresponding products in moderate to excellent yields under mild conditions.

  开发了一种高效的铑（III）催化的炔烃与丙烯酸直接氧化环化反应，形成α-吡喃酮。在此转化过程中，各种取代的丙烯酸是相容的，在温和的条件下以中等至极好的收率提供了相应的产物。
• 1,2-Disubstituted Heterocyclic Compounds
  申请人：Ripka Amy

  公开号：US20100137317A1

  公开（公告）日：2010-06-03

  1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Among the disorders which may be treated are neurological, neurodegenerative and psychiatric disorders including, but not limited to, those associated with cognitive deficits or schizophrenic symptoms.

  本文描述了抑制磷酸二酯酶10的1,2-二取代杂环化合物。同时还描述了这些化合物的制备过程、制药组合物、制药制剂以及在治疗哺乳动物（包括人类）的中枢神经系统（CNS）疾病和其他可能影响CNS功能的疾病中的制药用途。可治疗的疾病包括神经、神经退行性和精神障碍，包括但不限于与认知缺陷或精神分裂症状相关的疾病。
• Halogen-dependent coupling reaction of alkynes with (Z)-3-halopropenoates catalyzed by nickel
  作者：Martin Kotora、Masanori Ishikawa、Fu-Yu Tsai、Tamotsu Takahashi

  DOI：10.1016/s0040-4020(99)00182-9

  日期：1999.4

  Ni-catalyzed coupling reaction of alkynes with (Z)-3-halopropenoates depended on the halogen of halopropenoates. The reaction with (Z)-3-bromopropenoate afforded cyclopentadienes and the reaction with Q-3-iodopropenoates gave pyrones. (C) 1999 Elsevier Science Ltd. All rights reserved.