ethyl 4-O-anisoyl-2,3,6-tri-O-benzyl-1-thio-β-D-galactopyranoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 4-O-anisoyl-2,3,6-tri-O-benzyl-1-thio-β-D-galactopyranoside
• 英文别名: Bn(-2)[Bn(-3)][Bz(4-OMe)(-4)][Bn(-6)]Gal(b)-SEt；[(2R,3S,4S,5R,6S)-6-ethylsulfanyl-4,5-bis(phenylmethoxy)-2-(phenylmethoxymethyl)oxan-3-yl] 4-methoxybenzoate
• 化学式: C₃₇H₄₀O₇S
• 分子量: 628.786
• InChiKey: RJVXFIXDRMNQKW-COTSBLAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  45
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  97.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ethyl 4-O-anisoyl-2,3,6-tri-O-benzyl-1-thio-β-D-galactopyranoside 在 溴 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Synthesis of spacer-containing analogs of serogroup 6 pneumococcal oligosaccharides

  摘要：

  An efficient convergent strategy for the synthesis of a range of spacer-containing pneumococcal oligosaccharides of serogroup 6 and derivatives thereof has been developed. The spacer-containing oligosaccharides were deprotected and are available for subsequent conjugation and immunological studies, which are underway in our laboratory. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.03.035

文献信息

• Stereoselective 1,2-cis-galactosylation assisted by remote neighboring group participation and solvent effects
  作者：Alexei V. Demchenko、Emmanuel Rousson、Geert-Jan Boons

  DOI：10.1016/s0040-4039(99)01203-4

  日期：1999.9

  Iodonium-ion promoted glycosylations in 1,4-dioxane/toluene with galactosyl donors having an electron-donating neighboring group participating functionality at C-4 give exceptional high α-anomeric selectivities.

  碘鎓离子在1,4-二恶烷/甲苯中促进的糖基化反应以及在C-4上具有供电子的邻近基团参与官能团的半乳糖基供体赋予了极高的α-异头异构体选择性。
• Synthesis of spacer-containing analogs of serogroup 6 pneumococcal oligosaccharides
  作者：Archana R. Parameswar、Scott J. Hasty、Alexei V. Demchenko

  DOI：10.1016/j.carres.2008.03.035

  日期：2008.7

  An efficient convergent strategy for the synthesis of a range of spacer-containing pneumococcal oligosaccharides of serogroup 6 and derivatives thereof has been developed. The spacer-containing oligosaccharides were deprotected and are available for subsequent conjugation and immunological studies, which are underway in our laboratory. (C) 2008 Elsevier Ltd. All rights reserved.