5-methyl-3-(3-nitro-phenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methyl-3-(3-nitro-phenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester
• 英文别名: 5-Methyl-3-(3-nitro-phenyl)-1-phenyl-1H-pyrazol-4-carbonsaeure-aethylester；Ethyl 5-methyl-3-(3-nitrophenyl)-1-phenylpyrazole-4-carboxylate
• 化学式: C₁₉H₁₇N₃O₄
• 分子量: 351.362
• InChiKey: FOEMAVKUMOWBML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  89.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-丁炔酸乙酯 、 1-(3-nitrobenzylidene)-2-phenylhydrazine 在 mercury(II) diacetate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 5-methyl-3-(3-nitro-phenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester
  参考文献：
  名称：

  One-Pot Tandem Synthesis of Tetrasubstituted Pyrazoles via 1,3-Dipolar Cycloaddition Between Aryl Hydrazones and Ethyl But-2-ynoate

  摘要：

  1,3,4,5-Tetrasubstituted pyrazoles are rapidly and regioselectively synthesized in a one-pot, three-step sequence consisting of condensation, nitrilimine generation, and cycloaddition using mercuric acetate. Newly synthesized compounds were characterized by spectral studies. Regiochemistry of compounds 6a and 8a was determined as 1,4- and 1,5-regioisomers respectively by X-ray crystallography.

  DOI：

  10.1080/00397911.2014.891744

文献信息

• Sc(OTf)3-catalyzed, solvent-free domino synthesis of functionalized pyrazoles under controlled microwave irradiation
  作者：Kumkum Kumari、Dushyant Singh Raghuvanshi、Viatcheslav Jouikov、Krishna Nand Singh

  DOI：10.1016/j.tetlet.2011.12.094

  日期：2012.2

  An efficient, rapid, and green synthesis of functionalized pyrazoles has been accomplished under solvent-free conditions by the reaction of phenyl hydrazine, aldehydes and ethyl acetoacetate. This approach exploits the synthetic potential of microwave irradiation and scandium triflate combination and offers many advantages such as excellent product yields, shorter reaction time, easy isolation of products

  通过苯肼，醛和乙酰乙酸乙酯的反应，在无溶剂条件下完成了功能化吡唑的高效，快速和绿色合成。这种方法利用了微波辐射和三氟甲磺酸scan结合的合成潜力，并提供了许多优势，例如出色的产品收率，较短的反应时间，易于分离的产品以及对环境无害的反应条件。
• Minunni, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1905, vol. <5> 14 II, p. 418
  作者：Minunni

  DOI：——

  日期：——
• Minunni; Lazzarini, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1906, vol. <5> 15 I, p. 19
  作者：Minunni、Lazzarini

  DOI：——

  日期：——
• One-Pot Tandem Synthesis of Tetrasubstituted Pyrazoles via 1,3-Dipolar Cycloaddition Between Aryl Hydrazones and Ethyl But-2-ynoate
  作者：Srikantamurthy Ningaiah、Shridevi D. Doddaramappa、Chandra、Mahendra Madegowda、Shubakara Keshavamurthy、Umesha K. Bhadraiah

  DOI：10.1080/00397911.2014.891744

  日期：2014.8.3

  1,3,4,5-Tetrasubstituted pyrazoles are rapidly and regioselectively synthesized in a one-pot, three-step sequence consisting of condensation, nitrilimine generation, and cycloaddition using mercuric acetate. Newly synthesized compounds were characterized by spectral studies. Regiochemistry of compounds 6a and 8a was determined as 1,4- and 1,5-regioisomers respectively by X-ray crystallography.