4-chloromethyl-2-(N-methylamino)thiazole monohydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-chloromethyl-2-(N-methylamino)thiazole monohydrochloride
• 英文别名: 4-(Chloromethyl)-N-methyl-1,3-thiazol-2-amine hydrochloride；4-(chloromethyl)-N-methyl-1,3-thiazol-2-amine;hydrochloride
• 化学式: C₅H₇ClN₂S*ClH
• 分子量: 199.104
• InChiKey: FLZHZWYOYCFHOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  53.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-chloromethyl-2-(N-methylamino)thiazole monohydrochloride 在 乙酸酐 作用下， 生成 4-chloromethyl-2-(N-methylacetamido)thiazole
  参考文献：
  名称：

  Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical

  摘要：

  Benzhydrylpiperazinyl噻唑化合物的化学式为##STR1##其中R.sup.1为氢，氨基，或者单取代或双取代氨基，取代基选自较低的烷基，酰基和二(较低)烷基氨基甲烯，R.sup.2为氢，卤素，较低的烷基或芳基，R.sup.3为可选择地被卤素取代的芳基(较低)烷基，A为可选择地由硫原子中断的较低烷基，Y为C.sub.1 -C.sub.3烷基，具有抗过敏活性。

  公开号：

  US04411900A1

文献信息

• Thiazoline derivative and use of the same
  申请人：Kubo Keiji

  公开号：US20070010528A1

  公开（公告）日：2007-01-11

  A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X′ is a bond or —N(R 5 )—; Y is a divalent hydrocarbon group which may be substituted; Y′ is a bond or —C(═O)—; ring A is a nitrogen-containing heterocycle which may be substituted; Z 1 and Z 3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z 2 is a bond or —N(R 6 )—; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

  提供一种由式（I）表示的噻唑啉衍生物：其中R是环烃基，可以被取代，或者是可以被取代的杂环基; X是键或二价链烃基，可以被取代; X'是键或-N(R5)-; Y是二价烃基，可以被取代; Y'是键或-C(═O)-; 环A是含氮杂环，可以被取代; Z1和Z3各自独立地是键或二价链烃基，可以被取代; Z2是键或-N(R6)-; B是下式表示的基团：该化合物可用作治疗血栓症的药物。
• Thiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0032058A1

  公开（公告）日：1981-07-15

  The thiazole derivatives have the general formula:- wherein R1 is hydrogen, amino, or mono-or di-substituted amino, in which the substituent is selected from lower alkyl, acyl and di (lower) alkylaminomethylene, R2 is hydrogen, halogen, lower alkyl or aryl, R3 is ar(lower)alkyl optionally substituted by halogen, A is lower alkylene optionally interrupted by a sulfur atom, and Y is C1-C3 alkylene, and their pharmaceutically - acceptable salts, are useful as antiallergic agents.

  噻唑衍生物的通式如下 其中 R1 是氢、氨基或单或二取代氨基，其中取代基选自低级烷基、酰基和二（低级）烷基氨基亚甲基、 R2 是氢、卤素、低级烷基或芳基、 R3 是可选被卤素取代的 ar（低级）烷基、 A 是可选被硫原子打断的低级亚烷基，以及 Y 是 C1-C3 亚烷基，以及它们的药学上可接受的 盐可用作抗过敏剂。
• THIAZOLINE DERIVATIVE AND USE OF THE SAME
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1669352A1

  公开（公告）日：2006-06-14

  A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X' is a bond or -N(R5)-; Y is a divalent hydrocarbon group which may be substituted; Y' is a bond or -C(=O)-; ring A is a nitrogen-containing heterocycle which may be substituted; Z1 and Z3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z2 is a bond or -N(R6)-; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

  式 (I) 所代表的噻唑啉衍生物： 其中 R 是可被取代的环烃基或可被取代的杂环基；X 是键或可被取代的二价链烃基；X'是键或-N(R5)-；Y 是可被取代的二价烃基；Y'是键或-C(=O)-； 环 A 是可被取代的含氮杂环； Z1 和 Z3 各自独立地是键或可被取代的二价链烃基； Z2 是键或-N(R6)-； 以及 B 是由式表示的基团： 本发明提供了一种可作为血栓形成治疗药物的药物。
• US4411900A
  申请人：——

  公开号：US4411900A

  公开（公告）日：1983-10-25
• US7534887B2
  申请人：——

  公开号：US7534887B2

  公开（公告）日：2009-05-19