2-methoxy-4-phenyl-1H-imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methoxy-4-phenyl-1H-imidazole
• 英文别名: 2-methoxy-5-phenyl-1H-imidazole
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: QBRCEXXYJPIPBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  O-甲基异脲盐酸盐 、 2-溴苯乙酮 在 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以66%的产率得到2-methoxy-4-phenyl-1H-imidazole
  参考文献：
  名称：

  [EN] SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
  [FR] IMIDAZOLE CARBOXAMIDES SUBSTITUÉS ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES MÉDICAUX

  摘要：

  这项发明提供了替代咪唑羧酰胺及相关化合物，含有这些化合物的组合物，医疗工具包，以及使用这些化合物和组合物治疗患者的医疗障碍，例如癌症、溶酶体贮积症、神经退行性疾病、炎症性疾病等的方法。

  公开号：

  WO2021055612A1

文献信息

• PROCESS FOR PRODUCING POLYETHYLENE
  申请人：EASTMAN CHEMICAL COMPANY

  公开号：EP1159316A1

  公开（公告）日：2001-12-05
• PROCESS FOR PRODUCING POLYOLEFINS
  申请人：EASTMAN CHEMICAL COMPANY

  公开号：EP1171485A1

  公开（公告）日：2002-01-16
• SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
  申请人：Bial - R&D Investments, S.A.

  公开号：US20220411388A1

  公开（公告）日：2022-12-29

  The invention provides substituted imidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.
• [EN] PROCESS FOR PRODUCING POLYETHYLENE<br/>[FR] PROCEDE DE PRODUCTION DE POLYETHYLENE
  申请人：EASTMAN CHEM CO

  公开号：WO2000052068A1

  公开（公告）日：2000-09-08

  A novel process for producing homopolymers and copolymers of ethylene which involves contacting ethylene and/or ethylene and at least one or more other olefin(s) under polymerization conditions with a Ziegler-Natta type catalyst containing at least one or more internal electron donors, trimethylaluminum and at least one or more external electron donors containing at least one carbon-oxygen-carbon linkage (C-O-C) selected from the group consisting of Formula (1), R1-CH2-O-CH2-R2, Formula (2), Formula (3), R5-O-R6, and Formula (4), R?7-O(-R8-O)¿n-R9. Also provided are films and articles produced therefrom.
• [EN] PROCESS FOR PRODUCING POLYOLEFINS<br/>[FR] PROCEDE DE PRODUCTION DE POLYOLEFINES
  申请人：EASTMAN CHEM CO

  公开号：WO2000058372A1

  公开（公告）日：2000-10-05

  A novel process for producing homopolymers and interpolymers of olefins which involves contacting an olefin and/or an olefin and at least one or more other olefin(s) under polymerization conditions with a metallocene catalyst and at least one ether comprising at least one carbon-oxygen-carbon linkage (C-O-C) of the formula R?1-O(-R2-O)¿m-R3 in amounts sufficient to reduce the electrostatic charge in the polymerization medium. Also disclosed is a process for reducing electrostatic charge in an olefin polymerization medium.