1,4-bis-(1-phenyl-1H-[1,2,3]triazol-4-ylmethyl)-piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,4-bis-(1-phenyl-1H-[1,2,3]triazol-4-ylmethyl)-piperazine
• 英文别名: 1,4-Bis[(1-phenyltriazol-4-yl)methyl]piperazine；1,4-bis[(1-phenyltriazol-4-yl)methyl]piperazine
• 化学式: C₂₂H₂₄N₈
• 分子量: 400.486
• InChiKey: WEFKKJVCVCDUIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  哌嗪 、 3-溴丙炔 、 叠氮苯 在 三乙胺 、 copper(l) iodide 作用下， 以 水 为溶剂， 反应 11.0h， 以89%的产率得到1,4-bis-(1-phenyl-1H-[1,2,3]triazol-4-ylmethyl)-piperazine
  参考文献：
  名称：

  General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)-dialkylamines via a copper(I)-catalyzed three-component reaction in water

  摘要：

  A copper(l)-catalyzed three-component reaction to form (1 -substituted- 1H- 1,2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2005.07.060

文献信息

• General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)-dialkylamines via a copper(I)-catalyzed three-component reaction in water
  作者：Ze-Yi Yan、Ya-Bin Zhao、Ming-Jin Fan、Wei-Min Liu、Yong-Min Liang

  DOI：10.1016/j.tet.2005.07.060

  日期：2005.9

  A copper(l)-catalyzed three-component reaction to form (1 -substituted- 1H- 1,2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields. (c) 2005 Published by Elsevier Ltd.