N-(dicyclohexylmethyl)-N-(3-chloro-2-hydroxypropyl)amine

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: N-(dicyclohexylmethyl)-N-(3-chloro-2-hydroxypropyl)amine
• 英文别名: 1-chloro-3-(dicyclohexylmethylamino)propan-2-ol
• 化学式: C₁₆H₃₀ClNO
• 分子量: 287.873
• InChiKey: FCQSNWHINMOMNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己甲胺 、 环氧氯丙烷 在 甲醇 、 silica gel 、 氯仿 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以to obtain 8.2 g of N-(dicyclohexylmethyl)-N-(3-chloro-2-hydroxypropyl)amine的产率得到N-(dicyclohexylmethyl)-N-(3-chloro-2-hydroxypropyl)amine
  参考文献：
  名称：

  Carbostyril derivative

  摘要：

  该专利描述了一类化合物或其盐，其化学式为##STR1##其中A是C.sub.1-C.sub.6烷基；R.sup.1是C.sub.3-C.sub.8环烷基-C.sub.1-C.sub.6烷基，它可以具有一种从C.sub.1-C.sub.6烷氧羰基基团、羧基、C.sub.2-C.sub.6烷酰氧基-C.sub.1-C.sub.6烷基基团、氨基-C.sub.1-C.sub.6烷基基团、C.sub.1-C.sub.6烷基氨基-C.sub.1-C.sub.6烷基基团和羟基-C.sub.1-C.sub.6烷基基团中选择的基团、C.sub.3-C.sub.8环烷基、四氢吡喃基-C.sub.1-C.sub.6烷基、C.sub.1-C.sub.3烷二氧基基团取代的C.sub.1-C.sub.6烷基、苯基-C.sub.1-C.sub.6烷基，苯环上有1到3个从C.sub.1-C.sub.6烷基和羟基中选择的基团、或者是在C.sub.1-C.sub.6烷基上取代的哌啶基-C.sub.1-C.sub.6烷基；R.sup.2是5-元或6-元饱和或不饱和杂环-C.sub.1-C.sub.6烷基，所述杂环是从吡咯烷基、吗啉基、哌啶基、硫代吗啉基、咪唑基、1,2,4-三唑基、呋喃基、哌嗪基、吡啶基、四氢吡喃基和1,3-氧硫杂环基中选择的，可以在其上取代1到3个从羟基-C.sub.1-C.sub.6烷基基团、C.sub.2-C.sub.6烷酰氧基-C.sub.1-C.sub.6烷基基团、羟基、C.sub.1-C.sub.6烷基基团、氨基-C.sub.1-C.sub.6烷基基团、C.sub.1-C.sub.6烷基氨基-C.sub.1-C.sub.6烷基基团、C.sub.1-C.sub.6烷氧基基团、C.sub.1-C.sub.6烷氧基-C.sub.1-C.sub.6烷氧基基团、C.sub.1-C.sub.6烷氧基-C.sub.1-C.sub.6烷基基团、硫基和C.sub.1-C.sub.6烷基酰胺基团中选择的基团；在Carbostyril骨架中3-和4-位置之间的碳-碳键是单键或双键。该专利还涉及以该化合物作为活性成分的制药组合物。

  公开号：

  US05227381A1

文献信息

• CARBOSTYRIL DERIVATIVES
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0450066A1

  公开（公告）日：1991-10-09

  This invention relates to carbostyril derivatives represented by general formula (1), a process for their preparation, and an agent for inhibiting agglutination of platelets containing them as an active ingredient, wherein A represents a lower alkylene group, R1 represents a substituted or unsubstituted cycloalkyl-lower alkyl group, a cycloalkyl group, a tetrahydropyranyl* lower alkyl group, a lower alkylenedioxy-substituted lower alkyl group, a substituted phenyl-lower alkyl group or a lower alkyl-substituted piperidinyl-lower alkyl group, R2 represents a substituted or unsubstituted 5- or 6-membered, saturated or unsaturated heterocyclic-lower alkyl group, a tetrahydropyranylthio-lower alkyl group, a pyridylthio-lower alkyl group, a lower alkylene-dioxy-substituted lower alkyl group or a substituted or unsubstituted lower alkyl group, and the carbon-to-carbon bond between the 3- position and the 4-position of the carbostyril skeleton represents either a single or a double bond.

  本发明涉及通式(1)代表的碳化二氢吡啶衍生物、其制备工艺以及含有其作为活性成分的抑制血小板凝集的制剂，其中A代表低级亚烷基，R1代表取代或未取代的环烷基-低级烷基、环烷基、四氢吡喃基*低级烷基、低级亚烷基-二氧基取代的低级烷基、取代的苯基-低级烷基或低级烷基-取代的哌啶基-低级烷基、R2 代表取代或未取代的 5 或 6 元、饱和或不饱和杂环低级烷基、四氢吡喃硫基低级烷基、吡啶硫基低级烷基、亚烷基二氧基取代的低级烷基或取代或未取代的低级烷基，碳四吡啶骨架的 3 位和 4 位之间的碳-碳键代表单键或双键。
• US5227381A
  申请人：——

  公开号：US5227381A

  公开（公告）日：1993-07-13
• US5401740A
  申请人：——

  公开号：US5401740A

  公开（公告）日：1995-03-28
• Carbostyril derivative
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US05227381A1

  公开（公告）日：1993-07-13

  Carbostyril compounds or salts thereof of the formula ##STR1## wherein A is a C.sub.1 -C.sub.6 alkylene group; R.sup.1 is a C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl group which may have, as a substituent, a group selected from the group consisting of C.sub.1 -C.sub.6 alkoxycarbonyl groups, a carboxy group, C.sub.2 -C.sub.6 alkanoyloxy-C.sub.1 -C.sub.6 alkyl groups, amino-C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkylamino-C.sub.1 -C.sub.6 alkyl groups and hydroxy-C.sub.1 -C.sub.6 alkyl groups, a C.sub.3 -C.sub.8 cycloalkyl group, a tetrahydropyranyl-C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.3 alkylenedioxy group-substituted C.sub.1 -C.sub.6 alkyl group, a phenyl-C.sub.1 -C.sub.6 alkyl group having, as a substituent on the phenyl ring, 1 to 3 groups selected from the group consisting of C.sub.1 -C.sub.6 alkyl groups and a hydroxyl group, or a piperidinyl-C.sub.1 -C.sub.6 alkyl group having a C.sub.1 -C.sub.6 alkyl group as a substituent; R.sup.2 is a 5-membered or 6-membered saturated or unsaturated heterocyclic-C.sub.1 -C.sub.6 alkyl group, said heterocyclic being selected from the group consisting of pyrrolidinyl, morpholino, piperidinyl, thiomorpholino, imidazolyl, 1,2,4-triazolyl, furyl, piperazinyl, pyridyl, tetrahydropyranyl and 1,3-oxathiolranyl groups which may have, as a substituent thereon 1 to 3 groups selected from the group consisting of hydroxy-C.sub. 1 -C.sub.6 alkyl groups, C.sub.2 -C.sub.6 alkanoyloxy-C.sub.1 -C.sub.6 alkyl groups, a hydroxyl group, C.sub.1 -C.sub.6 alkyl groups, amino-C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkylamino-C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkoxy groups, C.sub.1 -C.sub.6 alkoxy-C.sub.1 -C.sub.6 alkoxy groups, C.sub.1 -C.sub.6 alkoxy-C.sub.1 -C.sub.6 alkyl groups, a thio group and C.sub.1 -C.sub.6 alkylamido groups; the carbon-carbon bond between the 3- and 4-positions in the carbostyril skeleton being a single bond or a double bond and pharmaceutical compositions containing the compound as the active ingredient.

  碳基喹啉化合物或其盐的化学式为##STR1##其中A为C.sub.1 -C.sub.6烷基链；R.sup.1为C.sub.3 -C.sub.8环烷基-C.sub.1 -C.sub.6烷基链，可能具有以下基团之一作为取代基：C.sub.1 -C.sub.6烷氧羰基，羧基，C.sub.2 -C.sub.6烷酰氧-C.sub.1 -C.sub.6烷基群，氨基-C.sub.1 -C.sub.6烷基群，C.sub.1 -C.sub.6烷基氨基-C.sub.1 -C.sub.6烷基群和羟基-C.sub.1 -C.sub.6烷基群，C.sub.3 -C.sub.8环烷基群，四氢吡喃基-C.sub.1 -C.sub.6烷基群，C.sub.1 -C.sub.3烷二氧基基团取代的C.sub.1 -C.sub.6烷基群，苯基-C.sub.1 -C.sub.6烷基群，在苯环上取代基为1至3个来自C.sub.1 -C.sub.6烷基群和羟基的基团，或者带有C.sub.1 -C.sub.6烷基群作为取代基的哌啶基-C.sub.1 -C.sub.6烷基群；R.sup.2为5-或6-成员饱和或不饱和杂环-C.sub.1 -C.sub.6烷基群，所述杂环选自吡咯啉基、吗啉基、哌啶基、硫代吗啉基、咪唑基、1,2,4-三唑基、呋基、哌嗪基、吡啶基、四氢吡喃基和1,3-氧硫杂环基团，可能具有以下基团之一作为取代基：羟基-C.sub.1 -C.sub.6烷基群，C.sub.2 -C.sub.6烷酰氧-C.sub.1 -C.sub.6烷基群，羟基，C.sub.1 -C.sub.6烷基群，氨基-C.sub.1 -C.sub.6烷基群，C.sub.1 -C.sub.6烷基氨基-C.sub.1 -C.sub.6烷基群，C.sub.1 -C.sub.6烷氧基群，C.sub.1 -C.sub.6烷氧-C.sub.1 -C.sub.6烷氧基群，C.sub.1 -C.sub.6烷氧-C.sub.1 -C.sub.6烷基群，硫基和C.sub.1 -C.sub.6烷基酰胺基团；在碳基喹啉骨架的3-位和4-位之间的碳-碳键为单键或双键，其中药物组合物含有该化合物作为活性成分。