2-[(E)-2-(2-phenyl-1H-indol-3-yl)vinyl]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[(E)-2-(2-phenyl-1H-indol-3-yl)vinyl]quinoline
• 英文别名: 2-[(E)-2-(2-phenyl-1H-indol-3-yl)ethenyl]quinoline
• 化学式: C₂₅H₁₈N₂
• 分子量: 346.431
• InChiKey: VRBTZFLJJHMVLN-WUKNDPDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基喹啉 、 2-苯基吲哚-3-甲醛 在 哌啶 作用下， 以 neat (no solvent) 为溶剂， 反应 4.0h， 以84%的产率得到2-[(E)-2-(2-phenyl-1H-indol-3-yl)vinyl]quinoline
  参考文献：
  名称：

  Microwave synthesis of 2-[(E)-2-(1H-indol-3-yl)vinyl]hetarenes

  摘要：

  A new highly efficient method for the condensation of (indol-3-yl)carbaldehydes with 2-methylazoles and 2-methylazines under activation with microwave irradiation is developed. The method provides high yields of structural scaffolds of bishetarylethylene fluorescent sensors that found widespread application in medicinal, bioorganic, and pharmaceutical chemistry.

  DOI：

  10.1007/s10593-015-1788-0

文献信息

• Microwave synthesis of 2-[(E)-2-(1H-indol-3-yl)vinyl]hetarenes
  作者：Alexander V. Aksenov、Oleg N. Nadein、Nicolai A. Aksenov、Anton A. Skomorokhov、Inna V. Aksenova、Michael A. Rubin

  DOI：10.1007/s10593-015-1788-0

  日期：2015.10

  A new highly efficient method for the condensation of (indol-3-yl)carbaldehydes with 2-methylazoles and 2-methylazines under activation with microwave irradiation is developed. The method provides high yields of structural scaffolds of bishetarylethylene fluorescent sensors that found widespread application in medicinal, bioorganic, and pharmaceutical chemistry.