(Z)-3-(2-nitrophenyl)-2-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)acrylic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-3-(2-nitrophenyl)-2-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)acrylic acid
• 化学式: C₁₅H₁₇NO₁₀
• 分子量: 371.301
• InChiKey: HTDJSSDRXVLBFA-POOJZCLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.16
• 重原子数：
  26.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  179.82
• 氢给体数：
  5.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  甲基硝基苯 在 potassium tert-butylate 、 水 、 lithium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 18.75h， 生成 (Z)-3-(2-nitrophenyl)-2-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)acrylic acid
  参考文献：
  名称：

  フェニルピルビン酸の抗糖尿病エノール型グルコシド

  摘要：

  This is a patent document related to a medication for lowering blood glucose levels in mammals with obesity, prediabetes, diabetes, obesity, and/or syndrome X. It provides phenylpyruvic acid anti-diabetic enol glycoside and its derivatives for use as a medication to normalize blood glucose levels. The compounds of the present invention help in managing blood glucose levels, maintaining balanced blood glucose levels, assisting in maintaining balanced blood glucose levels in humans with diabetes, promoting glucose uptake by cells, lowering blood glucose levels, improving or restoring glucose tolerance, optimizing blood glucose response, and normalizing glucose tolerance.

  公开号：

  JP2018087233A

文献信息

• ANTIDIABETIC ENOLIC GLUCOSIDE OF PHENYLPYRUVIC ACID
  申请人：Joubert Elizabeth

  公开号：US20130310331A1

  公开（公告）日：2013-11-21

  There is provided an antidiabetic enolic glucoside of phenylpyruvic acid and derivatives thereof for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pre-diabetic or have diabetes, obesity and/or syndrome X. Hence the compounds of the present invention help to manage blood sugar levels, i.e. helping the body by balancing the blood sugar levels; helping to keep balanced blood glucose levels, particularly in humans with diabetes; aiding by enhancing the glucose uptake by the cells and by reducing sugar levels, thus improving or restoring the glucose tolerance; optimizing the glycemic response; normalizing the glucose tolerance.

  提供了一种苯丙酮酸和其衍生物的抗糖尿病烯醇葡萄糖苷，用作药物，特别是用作正常血糖代理，即降低哺乳动物（肥胖、糖尿病前期或有糖尿病、肥胖和/或X综合症）的血糖水平至正常水平。因此，本发明的化合物有助于管理血糖水平，即通过平衡血糖水平来帮助身体；有助于保持平衡的血糖水平，特别是在患有糖尿病的人类中；通过增强细胞对葡萄糖的摄取并降低糖分水平，从而改善或恢复葡萄糖耐受性；优化糖代谢反应；正常化葡萄糖耐受性。