3-azido-2-methyl-butyric acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-azido-2-methyl-butyric acid
• 英文别名: 3-Azido-2-methylbutanoic acid；3-azido-2-methylbutanoic acid
• 化学式: C₅H₉N₃O₂
• 分子量: 143.145
• InChiKey: XAJCOOLVJPADJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  51.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  惕格酸 在 叠氮基三甲基硅烷 作用下， 以 neat (no solvent) 为溶剂， 反应 72.0h， 以90%的产率得到3-azido-2-methyl-butyric acid
  参考文献：
  名称：

  A Protocol for Accessing the β-Azidation of α,β-Unsaturated Carboxylic Acids

  摘要：

  This contribution reports the preparation and use of a new immobilized catalyst, PS-DABCOF (9), which has been specifically designed to access for the first time the efficient beta-azidation of alpha,beta-unsaturated carboxylic acids.

  DOI：

  10.1021/ol302069h

文献信息

• A Protocol for Accessing the β-Azidation of α,β-Unsaturated Carboxylic Acids
  作者：Tommaso Angelini、Simona Bonollo、Daniela Lanari、Ferdinando Pizzo、Luigi Vaccaro

  DOI：10.1021/ol302069h

  日期：2012.9.7

  This contribution reports the preparation and use of a new immobilized catalyst, PS-DABCOF (9), which has been specifically designed to access for the first time the efficient beta-azidation of alpha,beta-unsaturated carboxylic acids.