5-ethyl-2-{2-[4-(5-p-tolyl[1,3,4]oxadiazol-2-yl)phenoxy]ethyl}pyridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-ethyl-2-{2-[4-(5-p-tolyl[1,3,4]oxadiazol-2-yl)phenoxy]ethyl}pyridine
• 英文别名: 2-[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
• 化学式: C₂₄H₂₃N₃O₂
• 分子量: 385.466
• InChiKey: SRYOUUBOUAVBRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对甲基苯甲酸乙酯 在 chloroamine-T 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 5-ethyl-2-{2-[4-(5-p-tolyl[1,3,4]oxadiazol-2-yl)phenoxy]ethyl}pyridine
  参考文献：
  名称：

  Synthesis and antimicrobial studies of a new series of 2-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-5-substituted-1,3,4-oxadiazoles

  摘要：

  A series of novel 2-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-5-substituted-1,3,4-oxadiazoles were synthesized by the oxidative cyclisation of hydrazones derived from 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde and aroylhydrazines using chloramine-T as oxidant. IR, NMR and elemental analysis characterized the newly synthesized compounds. The synthesized compounds were evaluated for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Out of the compounds studied, compounds 8c and 8d showed significant inhibition. Compounds 8b, 8f, 8k and 8c showed moderate activity. The minimum inhibitory concentration of the compounds was in the range of 8-26 mu g ml(-1) against bacteria and 8-24 mu g ml(-1) against fungi. The title compounds represent a novel class of potent antimicrobial agents. (c) 2006 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.03.002

文献信息

• Synthesis and antimicrobial studies of a new series of 2-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-5-substituted-1,3,4-oxadiazoles
  作者：S.L. Gaonkar、K.M.L. Rai、B. Prabhuswamy

  DOI：10.1016/j.ejmech.2006.03.002

  日期：2006.7

  A series of novel 2-4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-5-substituted-1,3,4-oxadiazoles were synthesized by the oxidative cyclisation of hydrazones derived from 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde and aroylhydrazines using chloramine-T as oxidant. IR, NMR and elemental analysis characterized the newly synthesized compounds. The synthesized compounds were evaluated for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Out of the compounds studied, compounds 8c and 8d showed significant inhibition. Compounds 8b, 8f, 8k and 8c showed moderate activity. The minimum inhibitory concentration of the compounds was in the range of 8-26 mu g ml(-1) against bacteria and 8-24 mu g ml(-1) against fungi. The title compounds represent a novel class of potent antimicrobial agents. (c) 2006 Elsevier SAS. All rights reserved.