11-(tetrahydro-2H-pyran-2-yloxy)undecylamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 11-(tetrahydro-2H-pyran-2-yloxy)undecylamine
• 英文别名: 11-tetrahydropyranyloxyundecanylamine；11-(Oxan-2-yloxy)undecan-1-amine
• 化学式: C₁₆H₃₃NO₂
• 分子量: 271.444
• InChiKey: QATKSCKDFQVIGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  11-(tetrahydro-2H-pyran-2-yloxy)undecylamine 在 对甲苯磺酸 、 四丁基磷酸氢铵 、 三氯乙腈 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 33.0h， 生成 C₂₆H₃₂NO₅P^(2-)*2Na⁽¹⁺⁾
  参考文献：
  名称：

  The synthesis of 11-[(2-pyridyl)amino]- and 11-[(9-anthracenylcarbonyl)amino]undecyl phosphate and the study of their acceptor properties in the enzymatic reaction catalyzed by Salmonella galactosyl phosphotransferases

  摘要：

  Undecyl phosphate derivatives with new fluorescent labels, 11-[(2-pyridyl)amino]undecyl phosphate and 11-[(9-anthracenylcarbonyl)amino]undecyl phosphate, were synthesized. These compounds were shown to be acceptor substrates of the galactosyl phosphate residue in the enzymatic reaction catalyzed by galactosyl phosphotransferase from Salmonella anatum or Salmonella newport membrane preparations.

  DOI：

  10.1134/s1068162014010038
• 作为产物：
  描述：

  2-[11-(tetrahydro-2H-pyran-2-yloxy)undecyl]isoindolin-1,3-dione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以90%的产率得到11-(tetrahydro-2H-pyran-2-yloxy)undecylamine
  参考文献：
  名称：

  The synthesis of 11-[(2-pyridyl)amino]- and 11-[(9-anthracenylcarbonyl)amino]undecyl phosphate and the study of their acceptor properties in the enzymatic reaction catalyzed by Salmonella galactosyl phosphotransferases

  摘要：

  Undecyl phosphate derivatives with new fluorescent labels, 11-[(2-pyridyl)amino]undecyl phosphate and 11-[(9-anthracenylcarbonyl)amino]undecyl phosphate, were synthesized. These compounds were shown to be acceptor substrates of the galactosyl phosphate residue in the enzymatic reaction catalyzed by galactosyl phosphotransferase from Salmonella anatum or Salmonella newport membrane preparations.

  DOI：

  10.1134/s1068162014010038

文献信息

• Catechols as antimicrobial agents
  申请人：Merck & Co., Inc.

  公开号：US06348482B1

  公开（公告）日：2002-02-19

  Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.

  通用公式的化合物、药用可接受盐及其组合物，其中Ar为芳基和杂环芳基；R1、R2、R3和R4为氢、烷基、氰基、杂环芳基、羟基、氨基、酰胺基、卤素、烷氧基、芳氧基、羧酰胺基、烯基、环烷基、杂环烷基、酰基、酰氧基、羧酰烷氧基、羧基、硫、亚砜基、磺酰基和亚砜氧基，R5、R6、R7和R8为氢和低烷基；Het为含氮杂环环。
• Cyanoguanidines as cell proliferation inhibitors
  申请人：Leo Pharmaceutical Products, Ltd. A/S

  公开号：US06346520B1

  公开（公告）日：2002-02-12

  The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which formula R stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, carboxy, C1-C4 alkyl, alkoxy or alkoxycarbonyl, nitro, amino or cyano and Q stands for C5-C14 divalent hydrocarbon radical which can be straight, branched, cyclic, saturated or unsaturated and X stands for carboxy, C1-C4 alkoxycarbonyl, di(C1-C4 alkoxy)phosphinoyloxy, amino, C1-C4 alkoxycarbonylamino or tetrahydropyranyloxy; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.

  本发明涉及式（I）或其互变异构体的迄今未知的化合物，其中吡啶环的连接位于3-或4-位置，其中R代表一个或多个取代基，可以相同也可以不同，选自以下群组：氢，卤素，三氟甲基，羧基，C1-C4烷基，烷氧基或烷氧羰基，硝基，氨基或氰基，Q代表C5-C14双价的碳氢基团，可以是直链，支链，环状，饱和或不饱和的，X代表羧基，C1-C4烷氧羰基，二（C1-C4烷氧基）膦酰氧基，氨基，C1-C4烷氧羰胺基或四氢吡喃氧基；以及其药学上可接受的、无毒的盐和N-氧化物。这些化合物在人和兽医学实践中具有价值。
• CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS
  申请人：LEO PHARMA A/S (with secondary name: LEO PHARMACEUTICAL PRODUCTS LTD. A/S)

  公开号：EP0984936B1

  公开（公告）日：2003-09-03
• US6346520B1
  申请人：——

  公开号：US6346520B1

  公开（公告）日：2002-02-12
• US6646129B2
  申请人：——

  公开号：US6646129B2

  公开（公告）日：2003-11-11