(2S,3S)-2-(fluorenylmethoxycarbonylamino)-3-methylpentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,3S)-2-(fluorenylmethoxycarbonylamino)-3-methylpentanoic acid
• 英文别名: (2S,3S)-2-(9H-fluoren-1-ylmethoxycarbonylamino)-3-methylpentanoic acid
• 化学式: C₂₁H₂₃NO₄
• 分子量: 353.418
• InChiKey: NDNZKIQATHJUKP-DJJJIMSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-ethyl-3-(3-3-dimethylaminopropyl)carbodiimide hydrochloride 、 (2S,3S)-2-(fluorenylmethoxycarbonylamino)-3-methylpentanoic acid 、 1-羟基苯并三唑一水物 、 4-顺式-氟-L-脯氨酸氨基.盐酸盐 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 (2S,4S)-2-(aminocarbonyl)-1-[(2S,3S)-2-(fluorenylmethoxycarbonylamino)-3-methylpentanoyl]-4-fluoropyrrolidine
  参考文献：
  名称：

  EP1333025

  摘要：

  公开号：

文献信息

• Cyanopyrrolidine derivatives
  申请人：——

  公开号：US20040072892A1

  公开（公告）日：2004-04-15

  A cyanopyrrolidine derivative represented by Formula (1): 1 [wherein R 1 is a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, R 2 is a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, or R 1 and R 2 together form an oxo, a hydroxyimino group, an alkoxyimino group having 1 to 5 carbon atoms or an alkylidene group having 1 to 5 carbon atoms, R 3 and R 4 are each a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, or R 3 and R 4 together form an oxo, a hydroxyimino group, an alkoxyimino group having 1 to 5 carbon atoms or an alkylidene group having 1 to 5 carbon atoms, X is an oxygen atom or a sulfur atom, Y is —CR 5 R 6 — (wherein R 5 and R 6 are the same or different, and are each a hydrogen atom, a halogen atom, an optionally substituted alkyl group having 1 to 10 carbon atoms or an optionally substituted alkenyl group having 2 to 10 carbon atoms), or —CR 7 R 8 —CR 9 R 10 — (wherein R 7 , R 8 , R 9 and R 10 are the same or different, and each a hydrogen atom, a halogen atom or an optionally substituted alkyl group having 1 to 10 carbon atoms, or R 7 and R 9 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl group having 3 to 8 carbon atoms, an optionally substituted cycloalkenyl group having 4 to 8 carbon atoms, an optionally substituted bicycloalkyl group having 5 to 10 carbon atoms, or an optionally substituted bicycloalkenyl group having 5 to 10 carbon atoms) and Z is a hydrogen atom or an optionally substituted alkyl group having 1 to 10 carbon atoms, or Y and Z together with the nitrogen atom to which they are attached form an optionally substituted cyclic amino group having 2 to 10 carbon atoms], or a pharmaceutically acceptable salt thereof.

  一种由式（1）表示的氰基吡咯烷衍生物：1［其中R1是卤素原子，羟基，具有1至5个碳原子的烷氧基或具有1至5个碳原子的烷基，R2是氢原子，卤素原子，羟基，具有1至5个碳原子的烷氧基或具有1至5个碳原子的烷基，或R1和R2一起形成氧代，羟肟基，具有1至5个碳原子的烷氧肟基或具有1至5个碳原子的烷基亚甲基，R3和R4分别是氢原子，卤素原子，羟基，具有1至5个碳原子的烷氧基或具有1至5个碳原子的烷基，或R3和R4一起形成氧代，羟肟基，具有1至5个碳原子的烷氧肟基或具有1至5个碳原子的烷基亚甲基，X是氧原子或硫原子，Y是- CR5R6-（其中R5和R6相同或不同，且均为氢原子，卤素原子，具有1至10个碳原子的可选取代烷基或具有2至10个碳原子的可选取代烯基），或-CR7R8-CR9R10-（其中R7，R8，R9和R10相同或不同，且均为氢原子，卤素原子或具有1至10个碳原子的可选取代烷基，或R7和R9与它们附着的碳原子一起形成具有3至8个碳原子的可选取代环烷基，具有4至8个碳原子的可选取代环烯基，具有5至10个碳原子的可选取代双环烷基或具有5至10个碳原子的可选取代双环烯基），Z是氢原子或具有1至10个碳原子的可选取代烷基，或Y和Z与它们附着的氮原子一起形成具有2至10个碳原子的可选取代环氨基，或其药学上可接受的盐。
• CYANOPYRROLIDINE DERIVATIVES
  申请人：Fukushima Hiroshi

  公开号：US20070112059A1

  公开（公告）日：2007-05-17

  Cyanopyrrolidine compound represented by Formula (1): Wherein the substituents are as defined herein. The compounds inhibit dipeptidyl peptidase IV.

  公式（1）所代表的是Cyanopyrrolidine化合物：其中取代基如本文所定义。这些化合物抑制二肽基肽酶IV。
• Anti-infective nucleosides
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0346108A2

  公开（公告）日：1989-12-13

  The present invention relates to mono-, di- and tri- esters and ethers of 5-alkynyl-substituted pyrimidine nucleosides and their use in medical therapy particularly in the treatment and prophylaxis of herpes viral infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.

  本发明涉及 5-炔基取代的嘧啶核苷的单酯、双酯和三酯及醚，以及它们在医学治疗中的用途，特别是在疱疹病毒感染的治疗和预防中的用途。此外，还提供了根据本发明制备化合物的药物制剂和工艺。
• MODIFIED HYDROPHOBIC AUXILIARY MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Zhejiang Zhida Pharmaceutical Co., Ltd.

  公开号：EP3988538A1

  公开（公告）日：2022-04-27

  The present invention relates to the preparation of a hydrophobic medicinal auxiliary material and a drug-loaded fat emulsion, and in particular to a hydrophobic auxiliary material with the structural formula as shown below, wherein R is a hydrophobic natural compound or hydrophobic synthetic compound with one to three hydroxyl groups (n = 1-3); R1 is an α -amino protecting group, and R2 is an amino acid side chain, when m = 0, R reacts with an amino acid derivative with a protecting group by means of esterification to form a hydrophobic auxiliary material carrying the amino acid derivative with a protecting group; or when m = 1, R first introduces an amino acid linking arm of different chain lengths (1 = 1, 2, 4, 6) by means of an ester group, and then introduces an amino acid derivative with a protecting group to form a hydrophobic auxiliary material carrying an amino acid derivative polypeptide with a protecting group. The introduction of an amino acid derivative with an aromatic or alkoxycarbonyl or acyl amino protecting group on the hydrophobic auxiliary material is conducive to increasing the solubility of the drug in the hydrophobic auxiliary material, and improving the stability of the drug-loaded fat emulsion.

  本发明涉及一种疏水性药用辅助材料和载药脂肪乳剂的制备方法，特别是涉及一种结构式如下的疏水性辅助材料，其中R为具有1-3个羟基（n=1-3）的疏水性天然化合物或疏水性合成化合物；当 m = 0 时，R 通过酯化反应与带有保护基的氨基酸衍生物反应，形成带有保护基的氨基酸衍生物的疏水辅助材料；或当 m = 1 时，R 首先通过酯基引入不同链长（1 = 1、2、4、6）的氨基酸连接臂，然后引入带保护基的氨基酸衍生物，形成携带带保护基的氨基酸衍生物多肽的疏水性辅助材料。在疏水辅助材料上引入带有芳香族或烷氧基羰基或酰氨基保护基团的氨基酸衍生物，有利于增加药物在疏水辅助材料中的溶解度，提高载药脂肪乳剂的稳定性。
• [EN] POLYPEPTIDE COMPOUNDS USING PD-1 RECEPTORS AS TARGETS, PREPARATION METHOD THEREFOR AND USE THEREOF<br/>[FR] COMPOSÉS POLYPEPTIDIQUES UTILISANT DES RÉCEPTEURS PD-1 EN TANT QUE CIBLES, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION<br/>[ZH] 一类以PD-1受体为靶点的多肽化合物、其制备方法及应用
  申请人：[en]NANTONG UNIVERSITY;[zh]南通大学

  公开号：WO2022257831A1

  公开（公告）日：2022-12-15

  本发明公开了一类以PD-1受体为靶点的多肽化合物，多肽化合物包括化合物1、化合物2、化合物3、化合物4和化合物5；其中，化合物1-5的氨基酸序列如SEQ ID NO：1-5所示。本发明还公开了一类以PD-1受体为靶点的多肽化合物的制备方法，包括以下过程：利用固相合成方式，按照肽序列依次将化合物1-5的氨基酸偶联到固相树脂上，经过切割试剂裂解、冷冻干燥、制备纯化获得目的化合物。发明还公开了一类以PD-1受体为靶点的多肽化合物在制备镇痛药物的应用。本发明的小分子多肽：化合物1～5能够结合PD-1,鞘内给药下对炎症痛和内脏痛均具有显著的抑制效果；且合成简单，易纯化，利于大规模合成。