四硝基四氮唑蓝 | 1184-43-6

• 物质功能分类: 生物化工 - 生化试剂 - 生物染料
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 四硝基四氮唑蓝
• 中文别名: 硝基四唑兰；3,3"-(3,3"-二甲氧基[1,1"-联苯]-4,4"-二基)双[2,5-双(对硝基苯基)-2H-四唑鎓]；四硝基四氮唑蓝(TNBT)
• 英文名称: Tetranitro blue tetrazolium chloride
• 英文别名: 2-[4-[4-[3,5-bis(4-nitrophenyl)tetrazol-2-ium-2-yl]-3-methoxyphenyl]-2-methoxyphenyl]-3,5-bis(4-nitrophenyl)tetrazol-2-ium;dichloride
• CAS: 1184-43-6
• 化学式: C40H28Cl2N12O10
• 分子量: 907.6
• InChiKey: VCESGVLABVSDRO-UHFFFAOYSA-L

物化性质

• 熔点：
  ~170 °C (dec.)
• 溶解度：
  易溶于水、乙醇、甲醇、N,N二甲基甲酰胺
• 最大波长(λmax)：
  279 nm

计算性质

• 辛醇/水分配系数(LogP)：
  0.06
• 重原子数：
  64
• 可旋转键数：
  9
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  271
• 氢给体数：
  0
• 氢受体数：
  16

安全信息

• TSCA：
  Yes
• 危险等级：
  4.1
• 危险品标志：
  T
• 安全说明：
  S53
• 危险类别码：
  R45
• WGK Germany：
  3

制备方法与用途

用途：用于琥珀酸脱氢酶（succinate dehydrogenase）在细胞化学研究中的应用。

文献信息

• METHOD FOR DETERMINING THE PRODUCTION OF REACTIVE OXYGEN SPECIES IN A CELLULAR POPULATION
  申请人：Universitat Autònoma De Barcelona

  公开号：EP2637019A1

  公开（公告）日：2013-09-11

  The invention relates to a method for determining the production of reactive oxygen species in a cellular population. The invention also relates to a method for determining the need for an antioxidant treatment of a male subject, and to a method for identifying a substance that can reduce the reactive oxygen species in a cellular population.

  本发明涉及一种确定细胞群中活性氧产生情况的方法。本发明还涉及一种确定男性受试者是否需要抗氧化剂治疗的方法，以及一种确定能够减少细胞群中活性氧的物质的方法。
• Methods for coating surfaces with antimicrobial agents
  申请人：The Board of Regents of the University of Texas System

  公开号：US10589003B2

  公开（公告）日：2020-03-17

  Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.

  本发明公开了用抗菌剂涂覆或浸渍表面的方法，包括用包括抗菌剂和溶剂的组合物接触表面，并通过加热固化表面。还公开了降低需要使用医疗器械的受试者发生或恶化感染风险的方法，包括用抗菌剂涂覆或浸渍医疗器械表面，然后通过加热固化表面，从而降低发生或恶化感染的风险。
• Atp measurement method allowing visual judgement and reagent therefor
  申请人：——

  公开号：US20040142401A1

  公开（公告）日：2004-07-22

  The object of the invention is to provide a handy type visually determinable ATP measuring reagent which can be easily handled and has good measuring sensitivity. The invention is an ATP measuring reagent which rendered possible visual determination by amplifying the reaction to form glucose 6-phosphate from glucose through the joint use of ATP contained in a sample and acetyl phosphate contained in the reagent with glucokinase and acetate kinase contained in the reagent, and further leading it to a visualizable color reaction by the combination of glucose-6-phosphate dehydrogenase and diaphorase.

  本发明的目的是提供一种可目测测定的 ATP 测量试剂，该试剂操作简便，测量灵敏度高。本发明是一种 ATP 测量试剂，它通过样品中含有的 ATP 和试剂中含有的乙酰磷酸与试剂中含有的葡萄糖激酶和乙酸激酶共同作用，放大由葡萄糖生成 6-磷酸葡萄糖的反应，并通过葡萄糖-6-磷酸脱氢酶和二磷酸盐酶的结合，进一步将其引向可目视的颜色反应，从而使目视测定成为可能。
• ATP MEASUREMENT METHOD ALLOWING VISUAL JUDGEMENT AND REAGENT THEREFOR
  申请人：UNITIKA LTD.

  公开号：EP1445328B1

  公开（公告）日：2006-03-15
• Methods for coating and impregnating medical devices with antiseptic compositions
  申请人：Raad Issam

  公开号：US20050197634A1

  公开（公告）日：2005-09-08

  The present invention provides methods of coating or impregnating medical devices with an antiseptic composition that will inhibit or prevent the nosocomial infections typically associated with the use of such medical devices. The present invention further provides methods of coating or impregnating medical devices that produce devices with effective activity against infection, while avoiding destroying the devices or causing the devices to become toxic. In addition, the invention provides medical devices coated or impregnated with antiseptic compositions by the aforementioned novel methods.

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