7-hydroxy-3-carbethoxy-3,4-dihydrocoumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 3,4-二氢香豆素
• 英文名称: 7-hydroxy-3-carbethoxy-3,4-dihydrocoumarin
• 英文别名: Ethyl 7-hydroxy-2-oxo-3,4-dihydrochromene-3-carboxylate
• 化学式: C₁₂H₁₂O₅
• 分子量: 236.224
• InChiKey: WSBWGQINEKJDKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 7-(1-ethoxyethoxy)-2-oxochromene-3-carboxylate 、 L-Selectride 生成 7-hydroxy-3-carbethoxy-3,4-dihydrocoumarin
  参考文献：
  名称：

  BUCKLER, ROBERT T.;HATCH, ROBERT P.

  摘要：

  DOI：

文献信息

• Detection of hydrogen peroxide with optical indicator chalcogen compounds
  申请人：Miles Inc.

  公开号：US05081044A1

  公开（公告）日：1992-01-14

  Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and a method for using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.

  对氧化剂（例如过氧化氢）敏感的光学指示剂硒化物或硫化物化合物，以及使用这种指示剂的方法。在氧化过程中，产生的中间体会自发地消除硒化物残基，形成一个提供光学信号（如荧光）的信号化合物。首选的荧光指示剂化合物是3-硒-3,4-二氢香豆素衍生物和3-硒-3,4-二氢-2-喹啉衍生物。这种指示剂化合物在过氧化氢的氧化作用下会产生高度荧光的产物，并且在分析系统中非常有用，该系统根据所测定的分析物生成过氧化氢。
• Optical indicator 3,4-dihydro-2-quinolones
  申请人：Miles Inc.

  公开号：US04778893A1

  公开（公告）日：1988-10-18

  Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.

  对氧化剂（例如过氧化氢）敏感的光学指示剂硒化物或硫化物化合物，以及制备和使用这种指示剂的方法。在氧化过程中，产生的中间体会自发地消除硒或硫残基，从而产生提供光学信号（如荧光）的信号化合物。优选的荧光指示剂化合物是3-硒-3,4-二氢香豆素衍生物和3-硒-3,4-二氢-2-喹啉衍生物。这种指示剂化合物在过氧化氢氧化时产生高度荧光产物，并且在分析系统中非常有用，该系统根据待测物产生过氧化氢。
• Optical indicator chalcogen compounds and use
  申请人：MILES LABORATORIES, INC.

  公开号：EP0121743A2

  公开（公告）日：1984-10-17

  Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.

  对氧化剂（如过氧化氢）有反应的光学指示剂缩醛（硒化或硫化）化合物，以及制备和使用这种指示剂的方法。在氧化过程中，生成的中间体会自发地消除钙原残留物，从而产生一种信号化合物，该化合物可提供荧光等光学信号。首选的荧光指示剂化合物是 3-醛基-3,4-二氢香豆素衍生物和 3-醛基-3,4-二氢-2-喹啉酮衍生物。此类指示剂化合物在被过氧化氢氧化时会产生高荧光产物，在分析系统中非常有用，因为分析系统会根据所测定的分析物产生过氧化氢。
• BUCKLER, ROBERT T.;HATCH, ROBERT P.
  作者：BUCKLER, ROBERT T.、HATCH, ROBERT P.

  DOI：——

  日期：——
• US4778893A
  申请人：——

  公开号：US4778893A

  公开（公告）日：1988-10-18