(3,4-dichloro-phenyl)-[5-(1.4-dioxa-8-aza-spiro[4.5]dec-8-yl)-4-pyridin-4-yl-thiophen-2-yl]-methanon

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3,4-dichloro-phenyl)-[5-(1.4-dioxa-8-aza-spiro[4.5]dec-8-yl)-4-pyridin-4-yl-thiophen-2-yl]-methanon
• 英文别名: (3,4-Dichlorophenyl)-[5-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4-pyridin-4-ylthiophen-2-yl]methanone
• 化学式: C₂₃H₂₀Cl₂N₂O₃S
• 分子量: 475.395
• InChiKey: IQCCUUQVOHQFON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  79.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-3-(morpholin-4-yl)-2-(pyridin-4-yl)propenethione 、 2-溴-3',4'-二氯苯乙酮 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以35%的产率得到(3,4-dichloro-phenyl)-[5-(1.4-dioxa-8-aza-spiro[4.5]dec-8-yl)-4-pyridin-4-yl-thiophen-2-yl]-methanon
  参考文献：
  名称：

  WO2006/49891

  摘要：

  公开号：

文献信息

• Trisubstituted thiophenes as progesterone receptor modulators
  申请人：Jiang Weiqin

  公开号：US20060106047A1

  公开（公告）日：2006-05-18

  The present invention is directed to novel trisubstituted thiophene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical usage of these compounds are related to hormonal contraception, the treatment and/or prevention of secondary dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon or prostate. Additional uses of the invention include stimulation of food intake.

  本发明涉及新型三取代噻吩衍生物，含有它们的制药组合物以及它们在治疗或预防由孕激素受体激动剂和拮抗剂介导的疾病和疾病中的应用。这些化合物的临床用途涉及激素避孕，治疗和/或预防继发性痛经、闭经、功能性子宫出血、子宫平滑肌瘤、子宫内膜异位症、多囊卵巢综合症、子宫内膜、卵巢、乳腺、结肠或前列腺癌和腺癌。本发明的其他用途包括促进食物摄入。
• Trisubstituted Thiophenes as Progesterone Receptor Modulators
  申请人：Jiang Weiqin

  公开号：US20090306118A1

  公开（公告）日：2009-12-10

  The present invention is directed to novel trisubstituted thiophene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical usage of these compounds are related to hormonal contraception, the treatment and/or prevention of secondary dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon or prostate. Additional uses of the invention include stimulation of food intake.

  本发明涉及新型三取代噻吩衍生物，包含它们的药物组合物以及它们在治疗或预防由孕激素受体激动剂和拮抗剂介导的疾病和疾病中的应用。这些化合物的临床用途与激素避孕、治疗和/或预防继发性痛经、闭经、功能性子宫出血、子宫平滑肌瘤、子宫内膜异位症、多囊卵巢综合症、子宫内膜、卵巢、乳腺、结肠或前列腺癌和腺癌有关。本发明的其他用途包括促进食物摄入。
• TRISUBSTITUTED THIOPHENES AS PROGESTERONE RECEPTOR MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1807420B1

  公开（公告）日：2010-03-10
• US7638525B2
  申请人：——

  公开号：US7638525B2

  公开（公告）日：2009-12-29
• WO2006/49891
  申请人：——

  公开号：——

  公开（公告）日：——