4-oxo-N-phenyl-4-(4-phenylphenyl)butanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-oxo-N-phenyl-4-(4-phenylphenyl)butanamide
• 化学式: C₂₂H₁₉NO₂
• 分子量: 329.4
• InChiKey: DLGXSNOXUWYJBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] STABLE HEAVY ISOTOPES IN AMIDE FUNCTIONAL GROUPS AND USES THEREOF<br/>[FR] ISOTOPES LOURDS STABLES DANS DES GROUPES FONCTIONNELS AMIDE ET UTILISATIONS CORRESPONDANTES
  申请人：RISEN SUZHOU PHARMA TECH CO LTD

  公开号：WO2021189143A1

  公开（公告）日：2021-09-30

  There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided. (I)

  提供了含有稳定重同位素富集酰胺功能基团的化合物，用于调节药物或前药的药代动力学特性、代谢特性和/或传递效率，以及其治疗或预防效果和/或不良反应。还提供了使用富含同位素酰胺的药物和前药治疗或预防疾病状态和病症的方法。
• STABLE HEAVY ISOTOPES IN AMIDE FUNCTIONAL GROUPS AND USES THEREOF
  申请人：RISEN (SUZHOU) PHARMA TECH CO., LTD.

  公开号：US20220002285A1

  公开（公告）日：2022-01-06

  There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.