2,5-diamino-3-chloro-[1,4]benzoquinone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-diamino-3-chloro-[1,4]benzoquinone
• 英文别名: 2,5-Diamino-3-chlor-[1,4]benzochinon；2,5-Diamino-3-chlorocyclohexa-2,5-diene-1,4-dione
• 化学式: C₆H₅ClN₂O₂
• 分子量: 172.571
• InChiKey: CXCGJGOVROSKCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,5-diamino-3-chloro-[1,4]benzoquinone 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2,5-diamino-3-chloro-hydroquinone
  参考文献：
  名称：

  Cytokine Responses to Recombinant Cholera Toxin B Subunit Produced byBacillus brevisas a Mucosal Adjuvant

  摘要：

  AbstractWe attempted to clarify the mechanism of the mucosal adjuvanticity of recombinant cholera toxin B subunit (rCTB), which is inherently uncontaminated with the holotoxin produced by Bacillus brevis and has a powerful mucosal adjuvant activity, on cytokine responses compared with that of cholera toxin (CT). rCTB had no ability to stimulate cyclic AMP formation in mouse peritoneal macrophages (Mφ). Cytokine production by non‐immunized Mφ cultured with rCTB or CT and by the spleen cells of mice co‐immunized intranasally with ovalbumin (OVA) and rCTB or CT was examined. rCTB alone did not induce interleukin (IL)‐1α/β or IL‐6 production by Mφ, but combination of rCTB with lipopolysaccharide (LPS) enhanced both IL‐1α/β production. Conversely, CT plus LPS suppressed IL‐1α/β production more than LPS alone. Both rCTB and CT suppressed IL‐12 secretion induced by interferon γ (IFN γ) plus LPS. IL‐2, IL‐4, IL‐5, and IL‐10 were secreted by mouse spleen cells restimulated with OVA after intranasal co‐administration of OVA together with rCTB, and in response to CT, the same cytokines were secreted. The different effect of rCTB on Mφ from that of CT may mean a difference between the mechanisms of rCTB and CT during the early stage of an immune response.

  DOI：

  10.1111/j.1348-0421.2001.tb01276.x
• 作为产物：
  描述：

  2,6-二氯-1,4-苯醌 在 乙醇 、 氨 作用下， 生成 2,5-diamino-3-chloro-[1,4]benzoquinone
  参考文献：
  名称：

  Cytokine Responses to Recombinant Cholera Toxin B Subunit Produced byBacillus brevisas a Mucosal Adjuvant

  摘要：

  AbstractWe attempted to clarify the mechanism of the mucosal adjuvanticity of recombinant cholera toxin B subunit (rCTB), which is inherently uncontaminated with the holotoxin produced by Bacillus brevis and has a powerful mucosal adjuvant activity, on cytokine responses compared with that of cholera toxin (CT). rCTB had no ability to stimulate cyclic AMP formation in mouse peritoneal macrophages (Mφ). Cytokine production by non‐immunized Mφ cultured with rCTB or CT and by the spleen cells of mice co‐immunized intranasally with ovalbumin (OVA) and rCTB or CT was examined. rCTB alone did not induce interleukin (IL)‐1α/β or IL‐6 production by Mφ, but combination of rCTB with lipopolysaccharide (LPS) enhanced both IL‐1α/β production. Conversely, CT plus LPS suppressed IL‐1α/β production more than LPS alone. Both rCTB and CT suppressed IL‐12 secretion induced by interferon γ (IFN γ) plus LPS. IL‐2, IL‐4, IL‐5, and IL‐10 were secreted by mouse spleen cells restimulated with OVA after intranasal co‐administration of OVA together with rCTB, and in response to CT, the same cytokines were secreted. The different effect of rCTB on Mφ from that of CT may mean a difference between the mechanisms of rCTB and CT during the early stage of an immune response.

  DOI：

  10.1111/j.1348-0421.2001.tb01276.x

文献信息

• Anti-bacterial polymer and method for the preparation thereof, anti-bacterial polymer film and method for the preparation thereof, and article having such a film on the surface thereof
  申请人：ULVAC, INC.

  公开号：EP1396514A1

  公开（公告）日：2004-03-10

  An anti-bacterial polymer of the present invention consists of a vapor deposition-polymerization reaction product of a diaminobenzoic acid monomer or halogen atom-containing diamine monomer and a monomer reactive with these monomers. The anti-bacterial polymer can be prepared by a method, which comprises the step of subjecting a gas obtained by evaporating a diaminobenzoic acid monomer or halogen atom-containing diamine monomer and a gas obtained by evaporating a monomer reactive with these monomers to vapor deposition-polymerization, in a vacuum, to thus form an anti-bacterial polymer. The method permits the formation of a film having a desired thickness even on the surface having a complicated shape such as the surface of, for instance, a heat exchanger.

  本发明的抗菌聚合物由二氨基苯甲酸单体或含卤原子的二胺单体和与这些单体反应的单体的气相沉积-聚合反应产物组成。抗菌聚合物的制备方法包括以下步骤：将蒸发二氨基苯甲酸单体或含卤素原子的二胺单体得到的气体和蒸发与这些单体反应的单体得到的气体在真空中进行气相沉积-聚合反应，从而形成抗菌聚合物。这种方法即使在形状复杂的表面（如热交换器表面）上也能形成具有所需厚度的薄膜。
• US7279543B2
  申请人：——

  公开号：US7279543B2

  公开（公告）日：2007-10-09
• Cytokine Responses to Recombinant Cholera Toxin B Subunit Produced by<i>Bacillus brevis</i>as a Mucosal Adjuvant
  作者：Jun-ichi Maeyama、Masanori Isaka、Yoko Yasuda、Keiko Matano、Satoshi Kozuka、Tooru Taniguchi、Kunio Ohkuma、Kunio Tochikubo、Norihisa Goto

  DOI：10.1111/j.1348-0421.2001.tb01276.x

  日期：2001.2

  AbstractWe attempted to clarify the mechanism of the mucosal adjuvanticity of recombinant cholera toxin B subunit (rCTB), which is inherently uncontaminated with the holotoxin produced by Bacillus brevis and has a powerful mucosal adjuvant activity, on cytokine responses compared with that of cholera toxin (CT). rCTB had no ability to stimulate cyclic AMP formation in mouse peritoneal macrophages (Mφ). Cytokine production by non‐immunized Mφ cultured with rCTB or CT and by the spleen cells of mice co‐immunized intranasally with ovalbumin (OVA) and rCTB or CT was examined. rCTB alone did not induce interleukin (IL)‐1α/β or IL‐6 production by Mφ, but combination of rCTB with lipopolysaccharide (LPS) enhanced both IL‐1α/β production. Conversely, CT plus LPS suppressed IL‐1α/β production more than LPS alone. Both rCTB and CT suppressed IL‐12 secretion induced by interferon γ (IFN γ) plus LPS. IL‐2, IL‐4, IL‐5, and IL‐10 were secreted by mouse spleen cells restimulated with OVA after intranasal co‐administration of OVA together with rCTB, and in response to CT, the same cytokines were secreted. The different effect of rCTB on Mφ from that of CT may mean a difference between the mechanisms of rCTB and CT during the early stage of an immune response.