3-(1-butyl-1H-indol-3-yl)-3-(4-methoxyphenyl)-1-phenylpropan-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(1-butyl-1H-indol-3-yl)-3-(4-methoxyphenyl)-1-phenylpropan-1-one
• 英文别名: 3-(1-Butylindol-3-yl)-3-(4-methoxyphenyl)-1-phenylpropan-1-one；3-(1-butylindol-3-yl)-3-(4-methoxyphenyl)-1-phenylpropan-1-one
• 化学式: C₂₈H₂₉NO₂
• 分子量: 411.544
• InChiKey: QQIGSZXIWDPQRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-丁基吲哚 、 (E)-3-(4-甲氧基苯基)-1-苯基-丙-2-烯-1-酮 在 dodecatungstosilic acid 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以90%的产率得到3-(1-butyl-1H-indol-3-yl)-3-(4-methoxyphenyl)-1-phenylpropan-1-one
  参考文献：
  名称：

  A mild, efficient and improved protocol for the synthesis of novel indolyl crown ethers, di(indolyl)pyrazolyl methanes and 3-alkylated indoles using H4[Si(W3O10)3]

  摘要：

  Efficient electrophilic substitution reactions of indoles with various aldehydes proceed smoothly in acetonitrile using heteropoly acid (H-4[Si(W3O10)(3)]) to afford the corresponding new indolyl crown ethers and di(indolyl)pyrazolyl methanes. H-4[Si(W3O10)(3)] is also found to catalyze the Michael addition of indoles to alpha,beta-unsaturated compounds for the synthesis of 3-alkylated indoles. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.09.108

文献信息

• A mild, efficient and improved protocol for the synthesis of novel indolyl crown ethers, di(indolyl)pyrazolyl methanes and 3-alkylated indoles using H4[Si(W3O10)3]
  作者：Rajendran Murugan、Murugesan Karthikeyan、Paramasivam T. Perumal、Boreddy S.R. Reddy

  DOI：10.1016/j.tet.2005.09.108

  日期：2005.12

  Efficient electrophilic substitution reactions of indoles with various aldehydes proceed smoothly in acetonitrile using heteropoly acid (H-4[Si(W3O10)(3)]) to afford the corresponding new indolyl crown ethers and di(indolyl)pyrazolyl methanes. H-4[Si(W3O10)(3)] is also found to catalyze the Michael addition of indoles to alpha,beta-unsaturated compounds for the synthesis of 3-alkylated indoles. (c) 2005 Elsevier Ltd. All rights reserved.