1-hexyl-3-methyl-4-phenylazoline-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-hexyl-3-methyl-4-phenylazoline-2,5-dione
• 英文别名: 1-Hexyl-3-methyl-4-phenylpyrrole-2,5-dione；1-hexyl-3-methyl-4-phenylpyrrole-2,5-dione
• 化学式: C₁₇H₂₁NO₂
• 分子量: 271.359
• InChiKey: GNRIAHHKMRZIDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-苯基-1-丙炔 、 异氰酸己酯 、 一氧化碳 在 十二羰基三钌 作用下， 以 均三甲苯 为溶剂， 130.0 ℃ 、101.33 kPa 条件下， 反应 3.0h， 以95%的产率得到1-hexyl-3-methyl-4-phenylazoline-2,5-dione
  参考文献：
  名称：

  Ruthenium-catalyzed [2 + 2 + 1] Cocyclization of Isocyanates, Alkynes, and CO Enables the Rapid Synthesis of Polysubstituted Maleimides

  摘要：

  Intermolecular [2 + 2 + 1] cocyclization of isocyanates, alkynes, and CO (1 atm) proceeded smoothly in the presence of a catalytic amount of Ru3(CO)12 (3.3 mol %) in mesitylene at 130 degrees C for 3 approximately 42 h to give a variety of polysubstituted maleimides in excellent yields with high selectivity. The reaction may involve an azaruthenacyclopentenone intermediate derived from oxidative cyclization of an isocyanate and an alkyne on an active ruthenium species.

  DOI：

  10.1021/ja066305g

文献信息

• Ruthenium-catalyzed [2 + 2 + 1] Cocyclization of Isocyanates, Alkynes, and CO Enables the Rapid Synthesis of Polysubstituted Maleimides
  作者：Teruyuki Kondo、Masato Nomura、Yasuyuki Ura、Kenji Wada、Take-aki Mitsudo

  DOI：10.1021/ja066305g

  日期：2006.11.1

  Intermolecular [2 + 2 + 1] cocyclization of isocyanates, alkynes, and CO (1 atm) proceeded smoothly in the presence of a catalytic amount of Ru3(CO)12 (3.3 mol %) in mesitylene at 130 degrees C for 3 approximately 42 h to give a variety of polysubstituted maleimides in excellent yields with high selectivity. The reaction may involve an azaruthenacyclopentenone intermediate derived from oxidative cyclization of an isocyanate and an alkyne on an active ruthenium species.