4'-(p-toluenesulfonylamino)-2-hydroxychalcone | 72178-44-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4'-(p-toluenesulfonylamino)-2-hydroxychalcone
• 英文别名: N-[4-[(E)-3-(2-hydroxyphenyl)prop-2-enoyl]phenyl]-4-methylbenzenesulfonamide
• CAS: 72178-44-0
• 化学式: C₂₂H₁₉NO₄S
• 分子量: 393.463
• InChiKey: SIUDUBHPTJEPPP-XNTDXEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(4-乙酰基苯基)-4-甲基苯磺酰胺 、 水杨醛 以50%的产率得到
  参考文献：
  名称：

  MEHTA K. J.; PARIKH A. R., J. INST. CHEM. (INDIA), 1979, 51, NO 2, 60-61

  摘要：

  DOI：

文献信息

• Anti-cancer composition containing chalcone compounds
  申请人：Seoul National University Industry Foundation

  公开号：EP2601943A1

  公开（公告）日：2013-06-12

  The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.

  本发明涉及一种筛选抗癌化合物的方法和使用该方法筛选的抗癌化合物，更具体地说，涉及一种筛选抗癌化合物的方法，该方法包括：培养表达致癌蛋白跨膜4 L6家族成员5（TM4SF5）的癌细胞，该蛋白表达为SEQ ID NO：2的多肽表达的癌细胞，用抗癌候选物处理癌细胞，当抗癌候选物通过TM4SF5的分子机制对肿瘤的形成和转移表现出拮抗活性时，确定该抗癌候选物为抗癌物质。本发明还涉及使用该方法筛选出的具有抗癌活性的查尔酮化合物，以及包含该化合物作为有效成分的抗癌组合物。
• METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS
  申请人：Seoul National University Industry Foundation

  公开号：EP2099440A1

  公开（公告）日：2009-09-16
• METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5
  申请人：Seoul National University Industry Foundation

  公开号：EP2099440B1

  公开（公告）日：2013-02-27
• COMPOSITION FOR DIAGNOSING, TREATING, AND PREVENTING LIVER DISEASE
  申请人：Lee Jung Weon

  公开号：US20130178533A1

  公开（公告）日：2013-07-11

  The present invention relates to a composition for diagnosing, treating, and preventing liver disease, more particularly a composition for diagnosing liver disease comprising a material for measuring the grade of TM4SF5 (transmembrane 4 L six family member 5 or four-transmembrane L6 superfamily member 5) protein, a kit for diagnosing liver disease comprising the said composition, a method for providing information necessary for diagnosing liver disease composed of the following steps; measuring the level of TM4SF5 protein and the expressions and phosphorylations of TM4SF5 expression related signaling proteins; and comparing the measured levels with those of the normal control, a method for screening a material for treating liver disease, and a composition for treating or preventing liver disease comprising a material inhibiting TM4SF5 protein expression or the expressions and phosphorylations of TM4SF5 expression related signaling proteins.
• US8445722B2
  申请人：——

  公开号：US8445722B2

  公开（公告）日：2013-05-21