头孢拉啶 | 31828-50-9

• 物质功能分类: 原料药 - 抗生素类药物 - 头孢菌素类药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 中文名称: 头孢拉啶
• 中文别名: 头孢拉定水合物
• 英文名称: Cephradine dihydrate
• 英文别名: (6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrate
• CAS: 31828-50-9；58456-86-3
• 化学式: C16H23N3O6S
• 分子量: 385.4
• InChiKey: HBKDHIDYMXXJLI-OEDJVVDHSA-N

物化性质

• 熔点：
  183-185℃

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  140
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• BETA-LACTAMASE-RESISTANT CEPHALOSPORIN ESTER COMPOUNDS AND SALTS OF THEREOF
  申请人：Zhejiang Yongning Pharmaceutucal Factory

  公开号：EP1702921A1

  公开（公告）日：2006-09-20

  The present invention discloses the β-lactamase resistant cephalosporin ester compounds represented by the following formula (I), characterized in that the structures of the compounds are composed by connecting methyl ester residue of sulbactam halomethyl ester with carboxyl residue of semi-synthetic cephalosporins or salts of thereof. The present invention also provides the pharmaceutical salts of thereof, and the use of thereof in preparation of oral antibiotics.

  本发明公开了由下式（I）表示的抗β-内酰胺酶头孢菌素酯类化合物，其特征在于化合物的结构是由舒巴坦卤代甲酯的甲酯残基与半合成头孢菌素或其盐类的羧基残基连接而成。 本发明还提供了其药用盐，以及其在制备口服抗生素中的用途。
• Use of oxygen antagonists for the therapeutic treatment of mammals
  申请人：Fred Hutchinson Cancer Research Center

  公开号：EP2363022A2

  公开（公告）日：2011-09-07

  There is provided the use of oxygen antagonists for inducing stasis in cells, tissues and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia and cancer is provided.

  本发明提供了使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞的方法。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• USE OF OXYGEN ANTAGONISTS FOR EX VIVO PRESERVATION OF TISSUES OR ORGANS
  申请人：Fred Hutchinson Cancer Research Center

  公开号：EP2949212A1

  公开（公告）日：2015-12-02

  There is provided the use of oxygen antagonists for inducing stasis in cells, tissues and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia and cancer is provided.

  本发明提供了使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞的方法。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
  申请人：Roth B. Mark

  公开号：US20050136125A1

  公开（公告）日：2005-06-23

  The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer is provided.

  本发明涉及使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• Methods, compositions and devices for inducing stasis in tissues and organs
  申请人：Roth B. Mark

  公开号：US20050147692A1

  公开（公告）日：2005-07-07

  The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.

  本发明涉及使用氧拮抗剂诱导组织停滞，包括全部或部分器官。本发明包括实现组织停滞的方法和装置，以便保存和/或保护组织。在具体的实施方案中，本发明提供了为移植目的保存组织的保存方法和装置。