ethyl 1-(4-methoxyphenyl)-3-oxo-2,3-dihydro-1H-indene-2-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: ethyl 1-(4-methoxyphenyl)-3-oxo-2,3-dihydro-1H-indene-2-carboxylate
• 英文别名: ethyl (1R,2S)-1-(4-methoxyphenyl)-3-oxo-1,2-dihydroindene-2-carboxylate
• 化学式: C₁₉H₁₈O₄
• 分子量: 310.35
• InChiKey: UGAREVVDTBPCSD-SJORKVTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 2-benzoyl-3-(4-methoxyphenyl)acrylate 在 aluminum (III) chloride 作用下， 以77.778%的产率得到
  参考文献：
  名称：

  Electronic tuning cyclization of aryl-1,4-enediones: AlCl3-mediated Nazarov-type cyclization to synthesize polysubstituted-1-indanones

  摘要：

  An electronic tuning Nazarov-type cyclization protocol was proposed for the synthesis of polysubstituted-1-indanones from the readily available starting materials 1,4-enediones. AlCl3 was highlighted as the most efficient promoter for this reaction. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.10.052

文献信息

• Electronic tuning cyclization of aryl-1,4-enediones: AlCl3-mediated Nazarov-type cyclization to synthesize polysubstituted-1-indanones
  作者：Yan-Ping Zhu、Qun Cai、Feng-Cheng Jia、Mei-Cai Liu、Qing-He Gao、Xiang-Gao Meng、An-Xin Wu

  DOI：10.1016/j.tet.2014.10.052

  日期：2014.12

  An electronic tuning Nazarov-type cyclization protocol was proposed for the synthesis of polysubstituted-1-indanones from the readily available starting materials 1,4-enediones. AlCl3 was highlighted as the most efficient promoter for this reaction. (C) 2014 Elsevier Ltd. All rights reserved.