(5-(bis(5-methoxy-1H-indol-3-yl)methyl)-7-tert-butylbenzofuran-2-yl)(4-methoxyphenyl)methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-(bis(5-methoxy-1H-indol-3-yl)methyl)-7-tert-butylbenzofuran-2-yl)(4-methoxyphenyl)methanone
• 英文别名: [5-[bis(5-methoxy-1H-indol-3-yl)methyl]-7-tert-butyl-1-benzofuran-2-yl]-(4-methoxyphenyl)methanone
• 化学式: C₃₉H₃₆N₂O₅
• 分子量: 612.725
• InChiKey: LNGHMNKENHNRDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  46
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-叔丁基苯酚 在 碘 、 potassium carbonate 、 三氟乙酸 作用下， 以 乙腈 为溶剂， 反应 8.5h， 生成 (5-(bis(5-methoxy-1H-indol-3-yl)methyl)-7-tert-butylbenzofuran-2-yl)(4-methoxyphenyl)methanone
  参考文献：
  名称：

  Hybrid benzofuran–bisindole derivatives: New prototypes with promising anti-hyperlipidemic activities

  摘要：

  A series of different benzofuran bisindole hybrids were synthesized and evaluated in vitro for their antioxidant and in vivo for antidyslipidemic activity in triton WR-1339 induced hyperlipidemic rats. Among the series, compounds 4a, 4c, 4h and 4j showed significant decrease in plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) followed by increase in post heparin lipolytic activity (PHLA). In addition, the active hybrids possessed moderate antioxidant properties and increased the plasma lecithin cholesterol acyltransferase (LCAT) activity, which plays a key role in lipoprotein metabolism contributing to an increased level of HDL-C in serum. These results indicate that these hybrids constitute novel prototypes for the management of dyslipidemia. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.07.009

文献信息

• Hybrid benzofuran–bisindole derivatives: New prototypes with promising anti-hyperlipidemic activities
  作者：Koneni V. Sashidhara、Ram K. Modukuri、Ravi Sonkar、K. Bhaskara Rao、Gitika Bhatia

  DOI：10.1016/j.ejmech.2013.07.009

  日期：2013.10

  A series of different benzofuran bisindole hybrids were synthesized and evaluated in vitro for their antioxidant and in vivo for antidyslipidemic activity in triton WR-1339 induced hyperlipidemic rats. Among the series, compounds 4a, 4c, 4h and 4j showed significant decrease in plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) followed by increase in post heparin lipolytic activity (PHLA). In addition, the active hybrids possessed moderate antioxidant properties and increased the plasma lecithin cholesterol acyltransferase (LCAT) activity, which plays a key role in lipoprotein metabolism contributing to an increased level of HDL-C in serum. These results indicate that these hybrids constitute novel prototypes for the management of dyslipidemia. (C) 2013 Elsevier Masson SAS. All rights reserved.