3-(2-chlorobenzyl)-1,3-dimethylindolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2-chlorobenzyl)-1,3-dimethylindolin-2-one
• 英文别名: 3-[(2-Chlorophenyl)methyl]-1,3-dimethylindol-2-one；3-[(2-chlorophenyl)methyl]-1,3-dimethylindol-2-one
• 化学式: C₁₇H₁₆ClNO
• 分子量: 285.773
• InChiKey: OGGOWXODBPMUQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-氯-2-碘苯 在 copper(II) bis(trifluoromethanesulfonate) 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 18.0h， 生成 3-(2-chlorobenzyl)-1,3-dimethylindolin-2-one
  参考文献：
  名称：

  Copper-Catalyzed Diarylation of Activated Alkenes with Diaryliodonium Salts

  摘要：

  Cu(OTf)(2)-catalyzed diarylation of activated alkenes by using diaryliodonium(III) salts has been developed. With this method, arylated oxindoles can be easily accessed in good yields. Insights into the mechanism of copper-catalyzed arylations are discussed, and the findings are expected to help increase the level of understanding of catalytic arylations with diaryliodonium salts.

  DOI：

  10.1055/s-0033-1339004

文献信息

• Synthesis of 3,3-Disubstituted Oxindoles by Visible-Light-Mediated Radical Reactions of Aryl Diazonium Salts with N-Arylacrylamides
  作者：Weijun Fu、Fengjuan Xu、Yuqin Fu、Mei Zhu、Jiaqi Yu、Chen Xu、Dapeng Zou

  DOI：10.1021/jo401894b

  日期：2013.12.6

  A mild and efficient visible-light-mediated diarylation of N-arylacrylamides with aryl diazonium salts under mild conditions has been developed. This method provides convenient access to a variety of useful 3,3-disubstituted oxindoles by constructing two C-C bonds in one step.
• Copper-Catalyzed Diarylation of Activated Alkenes with Diaryliodonium Salts
  作者：Jianwei Han、Limin Wang、Yang Yang、Xunshen Wu、Song Mao、Jianjun Yu

  DOI：10.1055/s-0033-1339004

  日期：——

  Cu(OTf)(2)-catalyzed diarylation of activated alkenes by using diaryliodonium(III) salts has been developed. With this method, arylated oxindoles can be easily accessed in good yields. Insights into the mechanism of copper-catalyzed arylations are discussed, and the findings are expected to help increase the level of understanding of catalytic arylations with diaryliodonium salts.